A polymeric immunoglobulin—antigen fusion protein strategy for enhancing vaccine immunogenicity

In this study, a strategy based on polymeric immunoglobulin G scaffolds (PIGS) was used to produce a vaccine candidate for Mycobacterium tuberculosis. A genetic fusion construct comprising genes encoding the mycobacterial Ag85B antigen, an immunoglobulin γ‐chain fragment and the tailpiece from immun...

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Detalles Bibliográficos
Autores principales: Webster, Gina R., van Dolleweerd, Craig, Guerra, Thais, Stelter, Szymon, Hofmann, Sven, Kim, Mi‐Young, Teh, Audrey Y‐H., Diogo, Gil Reynolds, Copland, Alastair, Paul, Mathew J., Hart, Peter, Reljic, Rajko, Ma, Julian K‐C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230950/
https://www.ncbi.nlm.nih.gov/pubmed/29682888
http://dx.doi.org/10.1111/pbi.12932

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