Imepitoin Shows Benzodiazepine-Like Effects in Models of Anxiety

Imepitoin is a low affinity partial agonist for the benzodiazepine binding site of γ-aminobutyric acid (GABA(A)) receptors, and is currently used as an antiepileptic in dogs. Here we tested imepitoin for anxiolytic properties. In an in vitro model, imepitoin was capable of preventing the effect of c...

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Detalles Bibliográficos
Autores principales: Engel, Odilo, Masic, Aleksandar, Landsberg, Gary, Brooks, Melissa, Mills, Daniel S., Rundfeldt, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230983/
https://www.ncbi.nlm.nih.gov/pubmed/30455643
http://dx.doi.org/10.3389/fphar.2018.01225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230983/
https://www.ncbi.nlm.nih.gov/pubmed/30455643
http://dx.doi.org/10.3389/fphar.2018.01225

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