Cargando…
Comparison of sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine in pediatric dentistry
Background. The aim of this investigation was to compare the sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine combinations on fearful children needing dental treatment. Methods. This crossover double-blind clinical trial was conducted on 30 children aged 2‒6 years, who h...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Tabriz University of Medical Sciences
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231152/ https://www.ncbi.nlm.nih.gov/pubmed/30443309 http://dx.doi.org/10.15171/joddd.2018.034 |
_version_ | 1783370174458494976 |
---|---|
author | Mehran, Majid Ansari, Ghassem Vahid Golpayegani, Mojtaba Shayeghi, Shahnaz Shafiei, Leila |
author_facet | Mehran, Majid Ansari, Ghassem Vahid Golpayegani, Mojtaba Shayeghi, Shahnaz Shafiei, Leila |
author_sort | Mehran, Majid |
collection | PubMed |
description | Background. The aim of this investigation was to compare the sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine combinations on fearful children needing dental treatment. Methods. This crossover double-blind clinical trial was conducted on 30 children aged 2‒6 years, who had at least two similar teeth needing pulp treatment. Standard vital signs were recorded before and after premedication. Wilson sedation scale was used to judge the level of sedation. Cases were divided into two groups based on the sequence of medication received. This was to overcome the sequence effect. Group I received oral midazolam (0.4 mg/kg/chloral hydrate (50 mg/kg) at the first visit while they received midazolam (0.4 mg/kg)/promethazine (5 mg/kg) in their second visit. Group II received the premedication in the opposite sequence. The operator and child were blinded to the medication administered. Sedative efficacy of the two combinations were assessed and judged by two independent pediatric dentists based on the Wilson scale. Data were analyzed with ANOVA and paired t-test. Results. Only 10% of children who received chloral hydrate with midazolam exhibited high improvement in their behavior while 53% showed reasonable positive changes and 12% had no change or even deterioration of behavior. The difference between the effect of the two combination drugs was statistically significant (P<0.05) in favor of the chloral hydrate group. Conclusion. The results showed a significant difference in the sedation level induced between the two groups. Midazolam/chloral hydrate combination more effectively improved the co-operation for dental treatment. |
format | Online Article Text |
id | pubmed-6231152 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Tabriz University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-62311522018-11-15 Comparison of sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine in pediatric dentistry Mehran, Majid Ansari, Ghassem Vahid Golpayegani, Mojtaba Shayeghi, Shahnaz Shafiei, Leila J Dent Res Dent Clin Dent Prospects Original Article Background. The aim of this investigation was to compare the sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine combinations on fearful children needing dental treatment. Methods. This crossover double-blind clinical trial was conducted on 30 children aged 2‒6 years, who had at least two similar teeth needing pulp treatment. Standard vital signs were recorded before and after premedication. Wilson sedation scale was used to judge the level of sedation. Cases were divided into two groups based on the sequence of medication received. This was to overcome the sequence effect. Group I received oral midazolam (0.4 mg/kg/chloral hydrate (50 mg/kg) at the first visit while they received midazolam (0.4 mg/kg)/promethazine (5 mg/kg) in their second visit. Group II received the premedication in the opposite sequence. The operator and child were blinded to the medication administered. Sedative efficacy of the two combinations were assessed and judged by two independent pediatric dentists based on the Wilson scale. Data were analyzed with ANOVA and paired t-test. Results. Only 10% of children who received chloral hydrate with midazolam exhibited high improvement in their behavior while 53% showed reasonable positive changes and 12% had no change or even deterioration of behavior. The difference between the effect of the two combination drugs was statistically significant (P<0.05) in favor of the chloral hydrate group. Conclusion. The results showed a significant difference in the sedation level induced between the two groups. Midazolam/chloral hydrate combination more effectively improved the co-operation for dental treatment. Tabriz University of Medical Sciences 2018 2018-09-18 /pmc/articles/PMC6231152/ /pubmed/30443309 http://dx.doi.org/10.15171/joddd.2018.034 Text en © 2018 Mehran et al. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article published and distributed by Tabriz University of Medical Sciences under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Mehran, Majid Ansari, Ghassem Vahid Golpayegani, Mojtaba Shayeghi, Shahnaz Shafiei, Leila Comparison of sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine in pediatric dentistry |
title | Comparison of sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine in pediatric dentistry |
title_full | Comparison of sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine in pediatric dentistry |
title_fullStr | Comparison of sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine in pediatric dentistry |
title_full_unstemmed | Comparison of sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine in pediatric dentistry |
title_short | Comparison of sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine in pediatric dentistry |
title_sort | comparison of sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine in pediatric dentistry |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231152/ https://www.ncbi.nlm.nih.gov/pubmed/30443309 http://dx.doi.org/10.15171/joddd.2018.034 |
work_keys_str_mv | AT mehranmajid comparisonofsedativeeffectsoforalmidazolamchloralhydrateandmidazolampromethazineinpediatricdentistry AT ansarighassem comparisonofsedativeeffectsoforalmidazolamchloralhydrateandmidazolampromethazineinpediatricdentistry AT vahidgolpayeganimojtaba comparisonofsedativeeffectsoforalmidazolamchloralhydrateandmidazolampromethazineinpediatricdentistry AT shayeghishahnaz comparisonofsedativeeffectsoforalmidazolamchloralhydrateandmidazolampromethazineinpediatricdentistry AT shafieileila comparisonofsedativeeffectsoforalmidazolamchloralhydrateandmidazolampromethazineinpediatricdentistry |