Role of Additives during Deracemization Using Temperature Cycling

[Image: see text] Temperature cycling, alongside Viedma ripening, has been established as a reliable method for deracemizing racemic mixtures of chiral compounds that crystallize as a conglomerate. Here we report that the speed of temperature cycling can be increased by using chiral additives. We al...

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Autores principales: Belletti, Giuseppe, Meekes, Hugo, Rutjes, Floris P. J. T., Vlieg, Elias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231159/
https://www.ncbi.nlm.nih.gov/pubmed/30450016
http://dx.doi.org/10.1021/acs.cgd.8b00856
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author Belletti, Giuseppe
Meekes, Hugo
Rutjes, Floris P. J. T.
Vlieg, Elias
author_facet Belletti, Giuseppe
Meekes, Hugo
Rutjes, Floris P. J. T.
Vlieg, Elias
author_sort Belletti, Giuseppe
collection PubMed
description [Image: see text] Temperature cycling, alongside Viedma ripening, has been established as a reliable method for deracemizing racemic mixtures of chiral compounds that crystallize as a conglomerate. Here we report that the speed of temperature cycling can be increased by using chiral additives. We also demonstrate that the chirality of the additive determines the final enantiomeric state of the solid phase. Viedma ripening experiments using equivalent conditions, with and without chiral additives, are always found to be slower.
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spelling pubmed-62311592018-11-14 Role of Additives during Deracemization Using Temperature Cycling Belletti, Giuseppe Meekes, Hugo Rutjes, Floris P. J. T. Vlieg, Elias Cryst Growth Des [Image: see text] Temperature cycling, alongside Viedma ripening, has been established as a reliable method for deracemizing racemic mixtures of chiral compounds that crystallize as a conglomerate. Here we report that the speed of temperature cycling can be increased by using chiral additives. We also demonstrate that the chirality of the additive determines the final enantiomeric state of the solid phase. Viedma ripening experiments using equivalent conditions, with and without chiral additives, are always found to be slower. American Chemical Society 2018-10-02 2018-11-07 /pmc/articles/PMC6231159/ /pubmed/30450016 http://dx.doi.org/10.1021/acs.cgd.8b00856 Text en Copyright © 2018 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle Belletti, Giuseppe
Meekes, Hugo
Rutjes, Floris P. J. T.
Vlieg, Elias
Role of Additives during Deracemization Using Temperature Cycling
title Role of Additives during Deracemization Using Temperature Cycling
title_full Role of Additives during Deracemization Using Temperature Cycling
title_fullStr Role of Additives during Deracemization Using Temperature Cycling
title_full_unstemmed Role of Additives during Deracemization Using Temperature Cycling
title_short Role of Additives during Deracemization Using Temperature Cycling
title_sort role of additives during deracemization using temperature cycling
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231159/
https://www.ncbi.nlm.nih.gov/pubmed/30450016
http://dx.doi.org/10.1021/acs.cgd.8b00856
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