Inhibition of AKT suppresses the initiation and progression of BRCA1-associated mammary tumors

Despite the high incidence of BRCA1-mutant breast cancer, few substantial improvements in preventing or treating such cancers have been made. Using a Brca1-mutant mouse model, we examined the contribution of AKT to the incidence and growth of Brca1-mutated mammary tumors. A haploinsufficiency of Akt...

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Detalles Bibliográficos
Autores principales: Baek, Hye Jung, Kim, Sun Eui, Kim, Jong Kwang, Shin, Dong Hoon, Kim, Tae Hyun, Kim, Kwang Gi, Deng, Chu-Xia, Kim, Sang Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231214/
https://www.ncbi.nlm.nih.gov/pubmed/30443181
http://dx.doi.org/10.7150/ijbs.29242

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