Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP

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The transcriptional regulator YAP orchestrates many cellular functions, including tissue homeostasis, organ growth control, and tumorigenesis. Mechanical stimuli are a key input to YAP activity, but the mechanisms controlling this regulation remain largely uncharacterized. We show that CAV1 positive...

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Detalles Bibliográficos
Autores principales: Moreno-Vicente, Roberto, Pavón, Dácil María, Martín-Padura, Inés, Català-Montoro, Mauro, Díez-Sánchez, Alberto, Quílez-Álvarez, Antonio, López, Juan Antonio, Sánchez-Álvarez, Miguel, Vázquez, Jesús, Strippoli, Raffaele, del Pozo, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231326/
https://www.ncbi.nlm.nih.gov/pubmed/30404014
http://dx.doi.org/10.1016/j.celrep.2018.10.024
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