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Effects of Probiotic Supplementation on Selected Parameters of Blood Prooxidant‐Antioxidant Balance in Elite Athletes: A Double‐Blind Randomized Placebo‐Controlled Study

A randomized, double-blind, placebo-controlled study was conducted, in order to evaluate if Lactobacillus helveticus Lafti® L10 (Lallemand Health Solutions, Montreal, Canada) supplementation during three months could influence oxidative markers in the population of elite athletes: triathletes, cycli...

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Autores principales: Michalickova, Danica, Kotur-Stevuljevic, Jelena, Miljkovic, Milica, Dikic, Nenad, Kostic-Vucicevic, Marija, Andjelkovic, Marija, Koricanac, Vladimir, Djordjevic, Brizita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter Open 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231349/
https://www.ncbi.nlm.nih.gov/pubmed/30429904
http://dx.doi.org/10.1515/hukin-2017-0203
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author Michalickova, Danica
Kotur-Stevuljevic, Jelena
Miljkovic, Milica
Dikic, Nenad
Kostic-Vucicevic, Marija
Andjelkovic, Marija
Koricanac, Vladimir
Djordjevic, Brizita
author_facet Michalickova, Danica
Kotur-Stevuljevic, Jelena
Miljkovic, Milica
Dikic, Nenad
Kostic-Vucicevic, Marija
Andjelkovic, Marija
Koricanac, Vladimir
Djordjevic, Brizita
author_sort Michalickova, Danica
collection PubMed
description A randomized, double-blind, placebo-controlled study was conducted, in order to evaluate if Lactobacillus helveticus Lafti® L10 (Lallemand Health Solutions, Montreal, Canada) supplementation during three months could influence oxidative markers in the population of elite athletes: triathletes, cyclists and endurance athletes. Twenty-two elite athletes were randomized to either placebo (n = 12) or probiotic (n = 10) groups. The probiotic group received 2x1010 colony forming units of Lafti® L10. Before and after the supplementation serum samples were collected. Markers of oxidative stress and anti-oxidative defense: superoxide dismutase (SOD), paraoxonase (PON), advanced oxidation protein products (AOPP), malondialdehyde (MDA), total antioxidant status, total oxidant status, pro-oxidant-antioxidant balance, oxidative stress index, bilirubin, uric acid and albumin were determined in serum. Parameters of lipid status, as well as susceptibility to copper-induced oxidation of LDL particles in vitro were also determined. There was a significant interaction effect for MDA (p = 0.039), with a decrease in MDA in the probiotic group only (p = 0.049). There was a significant interaction effect for AOPP (p = 0.037), with a significant decrease in the probiotic group (p = 0.045). Interaction effect for SOD was approaching to formal significance (p = 0.108) and the post-hoc test showed a significant decrease in the probiotic group (p = 0.041) only. A significant correlation between AOPP and SOD (p = 0.012, r = -0.40) was found in the probiotic group at the end of the study. PON1 activity was decreased in both the probiotic (p = 0.032) and placebo group (p = 0.035). No significant changes in the remainder of the evaluated parameters were noted. In conclusion, probiotic strain Lafti® L10 exerts certain antioxidant potential, but further research is needed.
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spelling pubmed-62313492018-11-14 Effects of Probiotic Supplementation on Selected Parameters of Blood Prooxidant‐Antioxidant Balance in Elite Athletes: A Double‐Blind Randomized Placebo‐Controlled Study Michalickova, Danica Kotur-Stevuljevic, Jelena Miljkovic, Milica Dikic, Nenad Kostic-Vucicevic, Marija Andjelkovic, Marija Koricanac, Vladimir Djordjevic, Brizita J Hum Kinet Section II- Exercise Physiology & Sports Medicine A randomized, double-blind, placebo-controlled study was conducted, in order to evaluate if Lactobacillus helveticus Lafti® L10 (Lallemand Health Solutions, Montreal, Canada) supplementation during three months could influence oxidative markers in the population of elite athletes: triathletes, cyclists and endurance athletes. Twenty-two elite athletes were randomized to either placebo (n = 12) or probiotic (n = 10) groups. The probiotic group received 2x1010 colony forming units of Lafti® L10. Before and after the supplementation serum samples were collected. Markers of oxidative stress and anti-oxidative defense: superoxide dismutase (SOD), paraoxonase (PON), advanced oxidation protein products (AOPP), malondialdehyde (MDA), total antioxidant status, total oxidant status, pro-oxidant-antioxidant balance, oxidative stress index, bilirubin, uric acid and albumin were determined in serum. Parameters of lipid status, as well as susceptibility to copper-induced oxidation of LDL particles in vitro were also determined. There was a significant interaction effect for MDA (p = 0.039), with a decrease in MDA in the probiotic group only (p = 0.049). There was a significant interaction effect for AOPP (p = 0.037), with a significant decrease in the probiotic group (p = 0.045). Interaction effect for SOD was approaching to formal significance (p = 0.108) and the post-hoc test showed a significant decrease in the probiotic group (p = 0.041) only. A significant correlation between AOPP and SOD (p = 0.012, r = -0.40) was found in the probiotic group at the end of the study. PON1 activity was decreased in both the probiotic (p = 0.032) and placebo group (p = 0.035). No significant changes in the remainder of the evaluated parameters were noted. In conclusion, probiotic strain Lafti® L10 exerts certain antioxidant potential, but further research is needed. De Gruyter Open 2018-10-15 /pmc/articles/PMC6231349/ /pubmed/30429904 http://dx.doi.org/10.1515/hukin-2017-0203 Text en © 2018 Editorial Committee of Journal of Human Kinetics http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
spellingShingle Section II- Exercise Physiology & Sports Medicine
Michalickova, Danica
Kotur-Stevuljevic, Jelena
Miljkovic, Milica
Dikic, Nenad
Kostic-Vucicevic, Marija
Andjelkovic, Marija
Koricanac, Vladimir
Djordjevic, Brizita
Effects of Probiotic Supplementation on Selected Parameters of Blood Prooxidant‐Antioxidant Balance in Elite Athletes: A Double‐Blind Randomized Placebo‐Controlled Study
title Effects of Probiotic Supplementation on Selected Parameters of Blood Prooxidant‐Antioxidant Balance in Elite Athletes: A Double‐Blind Randomized Placebo‐Controlled Study
title_full Effects of Probiotic Supplementation on Selected Parameters of Blood Prooxidant‐Antioxidant Balance in Elite Athletes: A Double‐Blind Randomized Placebo‐Controlled Study
title_fullStr Effects of Probiotic Supplementation on Selected Parameters of Blood Prooxidant‐Antioxidant Balance in Elite Athletes: A Double‐Blind Randomized Placebo‐Controlled Study
title_full_unstemmed Effects of Probiotic Supplementation on Selected Parameters of Blood Prooxidant‐Antioxidant Balance in Elite Athletes: A Double‐Blind Randomized Placebo‐Controlled Study
title_short Effects of Probiotic Supplementation on Selected Parameters of Blood Prooxidant‐Antioxidant Balance in Elite Athletes: A Double‐Blind Randomized Placebo‐Controlled Study
title_sort effects of probiotic supplementation on selected parameters of blood prooxidant‐antioxidant balance in elite athletes: a double‐blind randomized placebo‐controlled study
topic Section II- Exercise Physiology & Sports Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231349/
https://www.ncbi.nlm.nih.gov/pubmed/30429904
http://dx.doi.org/10.1515/hukin-2017-0203
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