A Case of Posttransfusion Purpura with Severe Refractory Thrombocytopenia but No Cutaneous Manifestations

Posttransfusion purpura is a serious adverse effect of transfusion due to HPA-antibodies. A young female was diagnosed with acute leukaemia, and treatment commenced. Severe thrombocytopenia ensued. No platelet increment was achieved despite transfusions with buffy coat, HLA-compatible, and HPA-1a ne...

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Autores principales: Bhamra, Jagjit Singh, Iversen, Per Ole, Titze, Thomas Kjenner, Tjønnfjord, Geir Erland, Akkök, Çiğdem Akalın
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231382/
https://www.ncbi.nlm.nih.gov/pubmed/30510818
http://dx.doi.org/10.1155/2018/8187659
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author Bhamra, Jagjit Singh
Iversen, Per Ole
Titze, Thomas Kjenner
Tjønnfjord, Geir Erland
Akkök, Çiğdem Akalın
author_facet Bhamra, Jagjit Singh
Iversen, Per Ole
Titze, Thomas Kjenner
Tjønnfjord, Geir Erland
Akkök, Çiğdem Akalın
author_sort Bhamra, Jagjit Singh
collection PubMed
description Posttransfusion purpura is a serious adverse effect of transfusion due to HPA-antibodies. A young female was diagnosed with acute leukaemia, and treatment commenced. Severe thrombocytopenia ensued. No platelet increment was achieved despite transfusions with buffy coat, HLA-compatible, and HPA-1a negative platelets. The workup indicated the presence of anti-HPA-1a. When the diagnosis of posttransfusion purpura was sufficiently substantiated, she had experienced a fatal intracerebral haemorrhage.
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spelling pubmed-62313822018-12-03 A Case of Posttransfusion Purpura with Severe Refractory Thrombocytopenia but No Cutaneous Manifestations Bhamra, Jagjit Singh Iversen, Per Ole Titze, Thomas Kjenner Tjønnfjord, Geir Erland Akkök, Çiğdem Akalın Case Rep Hematol Case Report Posttransfusion purpura is a serious adverse effect of transfusion due to HPA-antibodies. A young female was diagnosed with acute leukaemia, and treatment commenced. Severe thrombocytopenia ensued. No platelet increment was achieved despite transfusions with buffy coat, HLA-compatible, and HPA-1a negative platelets. The workup indicated the presence of anti-HPA-1a. When the diagnosis of posttransfusion purpura was sufficiently substantiated, she had experienced a fatal intracerebral haemorrhage. Hindawi 2018-10-29 /pmc/articles/PMC6231382/ /pubmed/30510818 http://dx.doi.org/10.1155/2018/8187659 Text en Copyright © 2018 Jagjit Singh Bhamra et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Bhamra, Jagjit Singh
Iversen, Per Ole
Titze, Thomas Kjenner
Tjønnfjord, Geir Erland
Akkök, Çiğdem Akalın
A Case of Posttransfusion Purpura with Severe Refractory Thrombocytopenia but No Cutaneous Manifestations
title A Case of Posttransfusion Purpura with Severe Refractory Thrombocytopenia but No Cutaneous Manifestations
title_full A Case of Posttransfusion Purpura with Severe Refractory Thrombocytopenia but No Cutaneous Manifestations
title_fullStr A Case of Posttransfusion Purpura with Severe Refractory Thrombocytopenia but No Cutaneous Manifestations
title_full_unstemmed A Case of Posttransfusion Purpura with Severe Refractory Thrombocytopenia but No Cutaneous Manifestations
title_short A Case of Posttransfusion Purpura with Severe Refractory Thrombocytopenia but No Cutaneous Manifestations
title_sort case of posttransfusion purpura with severe refractory thrombocytopenia but no cutaneous manifestations
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231382/
https://www.ncbi.nlm.nih.gov/pubmed/30510818
http://dx.doi.org/10.1155/2018/8187659
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