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Renin-angiotensin inhibitors reprogram tumor immune microenvironment: A comprehensive view of the influences on anti-tumor immunity

Renin-angiotensin system inhibitors (RASi) have shown potential anti-tumor effects that may have a significant impact in cancer therapy. The components of the renin-angiotensin system (RAS) including both, conventional and alternative axis, appear to have contradictory effects on tumor biology. The...

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Autores principales: Vallejo-Ardila, Dora L., Fifis, Theodora, Burrell, Louise M., Walsh, Katrina, Christophi, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231452/
https://www.ncbi.nlm.nih.gov/pubmed/30464806
http://dx.doi.org/10.18632/oncotarget.26174
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author Vallejo-Ardila, Dora L.
Fifis, Theodora
Burrell, Louise M.
Walsh, Katrina
Christophi, Christopher
author_facet Vallejo-Ardila, Dora L.
Fifis, Theodora
Burrell, Louise M.
Walsh, Katrina
Christophi, Christopher
author_sort Vallejo-Ardila, Dora L.
collection PubMed
description Renin-angiotensin system inhibitors (RASi) have shown potential anti-tumor effects that may have a significant impact in cancer therapy. The components of the renin-angiotensin system (RAS) including both, conventional and alternative axis, appear to have contradictory effects on tumor biology. The mechanisms by which RASi impair tumor growth extend beyond their function of modulating tumor vasculature. The major focus of this review is to analyze other mechanisms by which RASi reprogram the tumor immune microenvironment. These involve impairing hypoxia and acidosis within the tumor stroma, regulating inflammatory signaling pathways and oxidative stress, modulating the function of the non-cellular components and immune cells, and regulating the cross-talk between kalli krein kinin system and RAS.
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spelling pubmed-62314522018-11-21 Renin-angiotensin inhibitors reprogram tumor immune microenvironment: A comprehensive view of the influences on anti-tumor immunity Vallejo-Ardila, Dora L. Fifis, Theodora Burrell, Louise M. Walsh, Katrina Christophi, Christopher Oncotarget Review Renin-angiotensin system inhibitors (RASi) have shown potential anti-tumor effects that may have a significant impact in cancer therapy. The components of the renin-angiotensin system (RAS) including both, conventional and alternative axis, appear to have contradictory effects on tumor biology. The mechanisms by which RASi impair tumor growth extend beyond their function of modulating tumor vasculature. The major focus of this review is to analyze other mechanisms by which RASi reprogram the tumor immune microenvironment. These involve impairing hypoxia and acidosis within the tumor stroma, regulating inflammatory signaling pathways and oxidative stress, modulating the function of the non-cellular components and immune cells, and regulating the cross-talk between kalli krein kinin system and RAS. Impact Journals LLC 2018-10-26 /pmc/articles/PMC6231452/ /pubmed/30464806 http://dx.doi.org/10.18632/oncotarget.26174 Text en Copyright: © 2018 Vallejo-Ardila et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Vallejo-Ardila, Dora L.
Fifis, Theodora
Burrell, Louise M.
Walsh, Katrina
Christophi, Christopher
Renin-angiotensin inhibitors reprogram tumor immune microenvironment: A comprehensive view of the influences on anti-tumor immunity
title Renin-angiotensin inhibitors reprogram tumor immune microenvironment: A comprehensive view of the influences on anti-tumor immunity
title_full Renin-angiotensin inhibitors reprogram tumor immune microenvironment: A comprehensive view of the influences on anti-tumor immunity
title_fullStr Renin-angiotensin inhibitors reprogram tumor immune microenvironment: A comprehensive view of the influences on anti-tumor immunity
title_full_unstemmed Renin-angiotensin inhibitors reprogram tumor immune microenvironment: A comprehensive view of the influences on anti-tumor immunity
title_short Renin-angiotensin inhibitors reprogram tumor immune microenvironment: A comprehensive view of the influences on anti-tumor immunity
title_sort renin-angiotensin inhibitors reprogram tumor immune microenvironment: a comprehensive view of the influences on anti-tumor immunity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231452/
https://www.ncbi.nlm.nih.gov/pubmed/30464806
http://dx.doi.org/10.18632/oncotarget.26174
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