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Pathogens in space: Advancing understanding of pathogen dynamics and disease ecology through landscape genetics

Landscape genetics has provided many insights into how heterogeneous landscape features drive processes influencing spatial genetic variation in free‐living organisms. This rapidly developing field has focused heavily on vertebrates, and expansion of this scope to the study of infectious diseases ho...

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Autores principales: Kozakiewicz, Christopher P., Burridge, Christopher P., Funk, W. Chris, VandeWoude, Sue, Craft, Meggan E., Crooks, Kevin R., Ernest, Holly B., Fountain‐Jones, Nicholas M., Carver, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231466/
https://www.ncbi.nlm.nih.gov/pubmed/30459828
http://dx.doi.org/10.1111/eva.12678
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author Kozakiewicz, Christopher P.
Burridge, Christopher P.
Funk, W. Chris
VandeWoude, Sue
Craft, Meggan E.
Crooks, Kevin R.
Ernest, Holly B.
Fountain‐Jones, Nicholas M.
Carver, Scott
author_facet Kozakiewicz, Christopher P.
Burridge, Christopher P.
Funk, W. Chris
VandeWoude, Sue
Craft, Meggan E.
Crooks, Kevin R.
Ernest, Holly B.
Fountain‐Jones, Nicholas M.
Carver, Scott
author_sort Kozakiewicz, Christopher P.
collection PubMed
description Landscape genetics has provided many insights into how heterogeneous landscape features drive processes influencing spatial genetic variation in free‐living organisms. This rapidly developing field has focused heavily on vertebrates, and expansion of this scope to the study of infectious diseases holds great potential for landscape geneticists and disease ecologists alike. The potential application of landscape genetics to infectious agents has garnered attention at formative stages in the development of landscape genetics, but systematic examination is lacking. We comprehensively review how landscape genetics is being used to better understand pathogen dynamics. We characterize the field and evaluate the types of questions addressed, approaches used and systems studied. We also review the now established landscape genetic methods and their realized and potential applications to disease ecology. Lastly, we identify emerging frontiers in the landscape genetic study of infectious agents, including recent phylogeographic approaches and frameworks for studying complex multihost and host‐vector systems. Our review emphasizes the expanding utility of landscape genetic methods available for elucidating key pathogen dynamics (particularly transmission and spread) and also how landscape genetic studies of pathogens can provide insight into host population dynamics. Through this review, we convey how increasing awareness of the complementarity of landscape genetics and disease ecology among practitioners of each field promises to drive important cross‐disciplinary advances.
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spelling pubmed-62314662018-11-20 Pathogens in space: Advancing understanding of pathogen dynamics and disease ecology through landscape genetics Kozakiewicz, Christopher P. Burridge, Christopher P. Funk, W. Chris VandeWoude, Sue Craft, Meggan E. Crooks, Kevin R. Ernest, Holly B. Fountain‐Jones, Nicholas M. Carver, Scott Evol Appl Reviews and Syntheses Landscape genetics has provided many insights into how heterogeneous landscape features drive processes influencing spatial genetic variation in free‐living organisms. This rapidly developing field has focused heavily on vertebrates, and expansion of this scope to the study of infectious diseases holds great potential for landscape geneticists and disease ecologists alike. The potential application of landscape genetics to infectious agents has garnered attention at formative stages in the development of landscape genetics, but systematic examination is lacking. We comprehensively review how landscape genetics is being used to better understand pathogen dynamics. We characterize the field and evaluate the types of questions addressed, approaches used and systems studied. We also review the now established landscape genetic methods and their realized and potential applications to disease ecology. Lastly, we identify emerging frontiers in the landscape genetic study of infectious agents, including recent phylogeographic approaches and frameworks for studying complex multihost and host‐vector systems. Our review emphasizes the expanding utility of landscape genetic methods available for elucidating key pathogen dynamics (particularly transmission and spread) and also how landscape genetic studies of pathogens can provide insight into host population dynamics. Through this review, we convey how increasing awareness of the complementarity of landscape genetics and disease ecology among practitioners of each field promises to drive important cross‐disciplinary advances. John Wiley and Sons Inc. 2018-07-28 /pmc/articles/PMC6231466/ /pubmed/30459828 http://dx.doi.org/10.1111/eva.12678 Text en © 2018 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews and Syntheses
Kozakiewicz, Christopher P.
Burridge, Christopher P.
Funk, W. Chris
VandeWoude, Sue
Craft, Meggan E.
Crooks, Kevin R.
Ernest, Holly B.
Fountain‐Jones, Nicholas M.
Carver, Scott
Pathogens in space: Advancing understanding of pathogen dynamics and disease ecology through landscape genetics
title Pathogens in space: Advancing understanding of pathogen dynamics and disease ecology through landscape genetics
title_full Pathogens in space: Advancing understanding of pathogen dynamics and disease ecology through landscape genetics
title_fullStr Pathogens in space: Advancing understanding of pathogen dynamics and disease ecology through landscape genetics
title_full_unstemmed Pathogens in space: Advancing understanding of pathogen dynamics and disease ecology through landscape genetics
title_short Pathogens in space: Advancing understanding of pathogen dynamics and disease ecology through landscape genetics
title_sort pathogens in space: advancing understanding of pathogen dynamics and disease ecology through landscape genetics
topic Reviews and Syntheses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231466/
https://www.ncbi.nlm.nih.gov/pubmed/30459828
http://dx.doi.org/10.1111/eva.12678
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