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Mouse Gambling Task reveals differential effects of acute sleep debt on decision-making and associated neurochemical changes
Sleep loss is associated with sleepiness, sustained attention, and memory deficits. However, vulnerability of higher cognitive processes (i.e. decision making) to sleep debt is less understood. Therefore, a major challenge is to understand why and how higher cognitive processes are affected by sleep...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231521/ https://www.ncbi.nlm.nih.gov/pubmed/30304537 http://dx.doi.org/10.1093/sleep/zsy168 |
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author | Pittaras, Elsa Callebert, Jacques Dorey, Rodolphe Chennaoui, Mounir Granon, Sylvie Rabat, Arnaud |
author_facet | Pittaras, Elsa Callebert, Jacques Dorey, Rodolphe Chennaoui, Mounir Granon, Sylvie Rabat, Arnaud |
author_sort | Pittaras, Elsa |
collection | PubMed |
description | Sleep loss is associated with sleepiness, sustained attention, and memory deficits. However, vulnerability of higher cognitive processes (i.e. decision making) to sleep debt is less understood. Therefore, a major challenge is to understand why and how higher cognitive processes are affected by sleep debt. We had established in mice correlations between individual decision-making strategies, prefrontal activity, and regional monoaminergic levels. Now, we show that acute sleep debt (ASD) disturbs decision-making processes and provokes brain regional modifications of serotonin and dopamine that could explain why ASD promotes inflexible and more risk-prone behaviors. Finally, we highlight, for the first time, that in a large group of healthy inbred mice some of them are more sensitive to ASD by showing inflexible behavior and decision-making deficits. We were also able to predict mice that would be the most vulnerable to ASD depending of their behavior before ASD exposure. |
format | Online Article Text |
id | pubmed-6231521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-62315212018-11-15 Mouse Gambling Task reveals differential effects of acute sleep debt on decision-making and associated neurochemical changes Pittaras, Elsa Callebert, Jacques Dorey, Rodolphe Chennaoui, Mounir Granon, Sylvie Rabat, Arnaud Sleep Basic Science of Sleep and Circadian Rhythms Sleep loss is associated with sleepiness, sustained attention, and memory deficits. However, vulnerability of higher cognitive processes (i.e. decision making) to sleep debt is less understood. Therefore, a major challenge is to understand why and how higher cognitive processes are affected by sleep debt. We had established in mice correlations between individual decision-making strategies, prefrontal activity, and regional monoaminergic levels. Now, we show that acute sleep debt (ASD) disturbs decision-making processes and provokes brain regional modifications of serotonin and dopamine that could explain why ASD promotes inflexible and more risk-prone behaviors. Finally, we highlight, for the first time, that in a large group of healthy inbred mice some of them are more sensitive to ASD by showing inflexible behavior and decision-making deficits. We were also able to predict mice that would be the most vulnerable to ASD depending of their behavior before ASD exposure. Oxford University Press 2018-10-10 /pmc/articles/PMC6231521/ /pubmed/30304537 http://dx.doi.org/10.1093/sleep/zsy168 Text en © Sleep Research Society 2018. Published by Oxford University Press [on behalf of the Sleep Research Society]. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Basic Science of Sleep and Circadian Rhythms Pittaras, Elsa Callebert, Jacques Dorey, Rodolphe Chennaoui, Mounir Granon, Sylvie Rabat, Arnaud Mouse Gambling Task reveals differential effects of acute sleep debt on decision-making and associated neurochemical changes |
title | Mouse Gambling Task reveals differential effects of acute sleep debt on decision-making and associated neurochemical changes |
title_full | Mouse Gambling Task reveals differential effects of acute sleep debt on decision-making and associated neurochemical changes |
title_fullStr | Mouse Gambling Task reveals differential effects of acute sleep debt on decision-making and associated neurochemical changes |
title_full_unstemmed | Mouse Gambling Task reveals differential effects of acute sleep debt on decision-making and associated neurochemical changes |
title_short | Mouse Gambling Task reveals differential effects of acute sleep debt on decision-making and associated neurochemical changes |
title_sort | mouse gambling task reveals differential effects of acute sleep debt on decision-making and associated neurochemical changes |
topic | Basic Science of Sleep and Circadian Rhythms |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231521/ https://www.ncbi.nlm.nih.gov/pubmed/30304537 http://dx.doi.org/10.1093/sleep/zsy168 |
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