Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections

The sepsis-induced cytokine storm leads to severe lymphopenia and reduced effector capacity of remaining/surviving cells. This results in a prolonged state of immunoparalysis, that contributes to enhanced morbidity/mortality of sepsis survivors upon secondary infection. The impact of sepsis on sever...

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Detalles Bibliográficos
Autores principales: Jensen, Isaac J., Winborn, Christina S., Fosdick, Micaela G., Shao, Peng, Tremblay, Mikaela M., Shan, Qiang, Tripathy, Sandeep Kumar, Snyder, Christopher M., Xue, Hai-Hui, Griffith, Thomas S., Houtman, Jon C., Badovinac, Vladimir P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231673/
https://www.ncbi.nlm.nih.gov/pubmed/30379932
http://dx.doi.org/10.1371/journal.ppat.1007405

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