Cargando…
Using a ResearchKit Smartphone App to Collect Rheumatoid Arthritis Symptoms From Real-World Participants: Feasibility Study
BACKGROUND: Using smartphones to enroll, obtain consent, and gather self-reported data from patients has the potential to enhance our understanding of disease burden and quantify physiological impact in the real world. It may also be possible to harness integral smartphone sensors to facilitate remo...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JMIR Publications
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231853/ https://www.ncbi.nlm.nih.gov/pubmed/30213779 http://dx.doi.org/10.2196/mhealth.9656 |
_version_ | 1783370315100848128 |
---|---|
author | Crouthamel, Michelle Quattrocchi, Emilia Watts, Sarah Wang, Sherry Berry, Pamela Garcia-Gancedo, Luis Hamy, Valentin Williams, Rachel E |
author_facet | Crouthamel, Michelle Quattrocchi, Emilia Watts, Sarah Wang, Sherry Berry, Pamela Garcia-Gancedo, Luis Hamy, Valentin Williams, Rachel E |
author_sort | Crouthamel, Michelle |
collection | PubMed |
description | BACKGROUND: Using smartphones to enroll, obtain consent, and gather self-reported data from patients has the potential to enhance our understanding of disease burden and quantify physiological impact in the real world. It may also be possible to harness integral smartphone sensors to facilitate remote collection of clinically relevant data. OBJECTIVE: We conducted the Patient Rheumatoid Arthritis Data From the Real World (PARADE) observational study using a customized ResearchKit app with a bring-your-own-device approach. Our objective was to assess the feasibility of using an entirely digital approach (social media and smartphone app) to conduct a real-world observational study of patients with rheumatoid arthritis. METHODS: We conducted this observational study using a customized ResearchKit app with a bring-your-own-device approach. To recruit patients, the PARADE app, designed to guide patients through a series of tasks, was publicized via social media platforms and made available for patients in the United States to download from the Apple App Store. We collected patient-reported data, such as medical history, rheumatoid arthritis-related medications (past and present), and a range of patient-reported outcome measures. We included in the assessment a joint-pain map and a novel objective assessment of wrist range of movement, measured by the smartphone-embedded gyroscope and accelerometer. RESULTS: Within 1 month of recruitment via social media campaigns, 399 participants self-enrolled, self-consented, and provided complete demographic data. Joint pain was the most frequently reported rheumatoid arthritis symptom to bother study participants (344/393, 87.5%). Severe patient-reported wrist pain appeared to be inversely linked with the range of wrist movement measured objectively by the app. At study entry, 292 of 399 participants (73.2%) indicated a preference for participating in a mobile app–based study. The number of participants in the study declined to 45 of 399 (11.3%) at week 12. CONCLUSIONS: Despite the declining number of participants over time, the combination of social media and smartphone app with sensor integration was a feasible and cost-effective approach for the collection of patient-reported data in rheumatoid arthritis. Integral sensors within smartphones can be harnessed to provide novel end points, and the novel wrist range of movement test warrants further clinical validation. |
format | Online Article Text |
id | pubmed-6231853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | JMIR Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-62318532018-12-03 Using a ResearchKit Smartphone App to Collect Rheumatoid Arthritis Symptoms From Real-World Participants: Feasibility Study Crouthamel, Michelle Quattrocchi, Emilia Watts, Sarah Wang, Sherry Berry, Pamela Garcia-Gancedo, Luis Hamy, Valentin Williams, Rachel E JMIR Mhealth Uhealth Original Paper BACKGROUND: Using smartphones to enroll, obtain consent, and gather self-reported data from patients has the potential to enhance our understanding of disease burden and quantify physiological impact in the real world. It may also be possible to harness integral smartphone sensors to facilitate remote collection of clinically relevant data. OBJECTIVE: We conducted the Patient Rheumatoid Arthritis Data From the Real World (PARADE) observational study using a customized ResearchKit app with a bring-your-own-device approach. Our objective was to assess the feasibility of using an entirely digital approach (social media and smartphone app) to conduct a real-world observational study of patients with rheumatoid arthritis. METHODS: We conducted this observational study using a customized ResearchKit app with a bring-your-own-device approach. To recruit patients, the PARADE app, designed to guide patients through a series of tasks, was publicized via social media platforms and made available for patients in the United States to download from the Apple App Store. We collected patient-reported data, such as medical history, rheumatoid arthritis-related medications (past and present), and a range of patient-reported outcome measures. We included in the assessment a joint-pain map and a novel objective assessment of wrist range of movement, measured by the smartphone-embedded gyroscope and accelerometer. RESULTS: Within 1 month of recruitment via social media campaigns, 399 participants self-enrolled, self-consented, and provided complete demographic data. Joint pain was the most frequently reported rheumatoid arthritis symptom to bother study participants (344/393, 87.5%). Severe patient-reported wrist pain appeared to be inversely linked with the range of wrist movement measured objectively by the app. At study entry, 292 of 399 participants (73.2%) indicated a preference for participating in a mobile app–based study. The number of participants in the study declined to 45 of 399 (11.3%) at week 12. CONCLUSIONS: Despite the declining number of participants over time, the combination of social media and smartphone app with sensor integration was a feasible and cost-effective approach for the collection of patient-reported data in rheumatoid arthritis. Integral sensors within smartphones can be harnessed to provide novel end points, and the novel wrist range of movement test warrants further clinical validation. JMIR Publications 2018-09-13 /pmc/articles/PMC6231853/ /pubmed/30213779 http://dx.doi.org/10.2196/mhealth.9656 Text en ©Michelle Crouthamel, Emilia Quattrocchi, Sarah Watts, Sherry Wang, Pamela Berry, Luis Garcia-Gancedo, Valentin Hamy, Rachel E Williams. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 13.09.2018. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR mhealth and uhealth, is properly cited. The complete bibliographic information, a link to the original publication on http://mhealth.jmir.org/, as well as this copyright and license information must be included. |
spellingShingle | Original Paper Crouthamel, Michelle Quattrocchi, Emilia Watts, Sarah Wang, Sherry Berry, Pamela Garcia-Gancedo, Luis Hamy, Valentin Williams, Rachel E Using a ResearchKit Smartphone App to Collect Rheumatoid Arthritis Symptoms From Real-World Participants: Feasibility Study |
title | Using a ResearchKit Smartphone App to Collect Rheumatoid Arthritis Symptoms From Real-World Participants: Feasibility Study |
title_full | Using a ResearchKit Smartphone App to Collect Rheumatoid Arthritis Symptoms From Real-World Participants: Feasibility Study |
title_fullStr | Using a ResearchKit Smartphone App to Collect Rheumatoid Arthritis Symptoms From Real-World Participants: Feasibility Study |
title_full_unstemmed | Using a ResearchKit Smartphone App to Collect Rheumatoid Arthritis Symptoms From Real-World Participants: Feasibility Study |
title_short | Using a ResearchKit Smartphone App to Collect Rheumatoid Arthritis Symptoms From Real-World Participants: Feasibility Study |
title_sort | using a researchkit smartphone app to collect rheumatoid arthritis symptoms from real-world participants: feasibility study |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231853/ https://www.ncbi.nlm.nih.gov/pubmed/30213779 http://dx.doi.org/10.2196/mhealth.9656 |
work_keys_str_mv | AT crouthamelmichelle usingaresearchkitsmartphoneapptocollectrheumatoidarthritissymptomsfromrealworldparticipantsfeasibilitystudy AT quattrocchiemilia usingaresearchkitsmartphoneapptocollectrheumatoidarthritissymptomsfromrealworldparticipantsfeasibilitystudy AT wattssarah usingaresearchkitsmartphoneapptocollectrheumatoidarthritissymptomsfromrealworldparticipantsfeasibilitystudy AT wangsherry usingaresearchkitsmartphoneapptocollectrheumatoidarthritissymptomsfromrealworldparticipantsfeasibilitystudy AT berrypamela usingaresearchkitsmartphoneapptocollectrheumatoidarthritissymptomsfromrealworldparticipantsfeasibilitystudy AT garciagancedoluis usingaresearchkitsmartphoneapptocollectrheumatoidarthritissymptomsfromrealworldparticipantsfeasibilitystudy AT hamyvalentin usingaresearchkitsmartphoneapptocollectrheumatoidarthritissymptomsfromrealworldparticipantsfeasibilitystudy AT williamsrachele usingaresearchkitsmartphoneapptocollectrheumatoidarthritissymptomsfromrealworldparticipantsfeasibilitystudy |