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We miss the opportunity: Pretreament of osteoporosis in a German trauma center

Osteoporosis remains a major health concern due to high incidence of fragility fractures followed by higher mortality and morbidity. Implementation of guidelines for diagnosis and treatment of osteoporosis is critically discussed internationally. Aim of this study was to evaluate implementation of t...

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Autores principales: Rausch, Valentin, Schwarzer, Andreas, Dietrich, Johannes W., Kaisler, Miriam, Seybold, Dominik, Vollert, Jan, Schildhauer, Thomas A., Maier, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231904/
https://www.ncbi.nlm.nih.gov/pubmed/30418992
http://dx.doi.org/10.1371/journal.pone.0207122
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author Rausch, Valentin
Schwarzer, Andreas
Dietrich, Johannes W.
Kaisler, Miriam
Seybold, Dominik
Vollert, Jan
Schildhauer, Thomas A.
Maier, Christoph
author_facet Rausch, Valentin
Schwarzer, Andreas
Dietrich, Johannes W.
Kaisler, Miriam
Seybold, Dominik
Vollert, Jan
Schildhauer, Thomas A.
Maier, Christoph
author_sort Rausch, Valentin
collection PubMed
description Osteoporosis remains a major health concern due to high incidence of fragility fractures followed by higher mortality and morbidity. Implementation of guidelines for diagnosis and treatment of osteoporosis is critically discussed internationally. Aim of this study was to evaluate implementation of these guidelines regarding diagnosis and therapy of osteoporosis in a developed western country. We hypothesized that (a) prior diagnosis of osteoporosis in patients with low-energy fractures is higher than the estimated incidence and (b) diagnosis and therapy of osteoporosis in patients with prior low-energy fractures is higher than in patients without prior low-energy fractures. 399 patients >60 years suffering low-energy-fractures of their spine, femur, humerus or forearm between 03/2014 and 04/2015 were recruited in a German trauma center. All received a standardized interview. In 21% (84/399) of all patients, osteoporosis was diagnosed prior to current admission. 34% (136/399) suffered a prior risk-fracture after age of 50. Of these, only 54% (73/136) reported about following dual-energy X-ray absorptiometry (DXA) to test for decreased bone-marrow-density with positive results in 68% (50/73). 38% (19/50) of these patients with fragility fractures and prior osteoporosis diagnosis received anti-osteoporotic medication. 66% (263/399) of all patients had no prior risk-fracture and were tested for osteoporosis by DXA in 36% (95/263), leading to positive results in 34% (32/95). 44% (14/32) of these patients received anti-osteoporotic medication. Applying FRAX, 33% of all patients showed a calculated 10-year-risk >20% for suffering a major osteoporotic fracture. 61% (83/136) of patients with a prior fracture had a 10-year-risk >20% of which 47% (39/83) patients received no prior DXA. Although guidelines recommend diagnosis and treatment of patients with low-energy fractures, opportunity for early treatment following risk fractures seems rarely used. Expedient risk assessment is necessary to indicate further diagnostics and therapy of osteoporosis to ensure adequate and efficient treatment for osteoporotic fractures.
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spelling pubmed-62319042018-11-19 We miss the opportunity: Pretreament of osteoporosis in a German trauma center Rausch, Valentin Schwarzer, Andreas Dietrich, Johannes W. Kaisler, Miriam Seybold, Dominik Vollert, Jan Schildhauer, Thomas A. Maier, Christoph PLoS One Research Article Osteoporosis remains a major health concern due to high incidence of fragility fractures followed by higher mortality and morbidity. Implementation of guidelines for diagnosis and treatment of osteoporosis is critically discussed internationally. Aim of this study was to evaluate implementation of these guidelines regarding diagnosis and therapy of osteoporosis in a developed western country. We hypothesized that (a) prior diagnosis of osteoporosis in patients with low-energy fractures is higher than the estimated incidence and (b) diagnosis and therapy of osteoporosis in patients with prior low-energy fractures is higher than in patients without prior low-energy fractures. 399 patients >60 years suffering low-energy-fractures of their spine, femur, humerus or forearm between 03/2014 and 04/2015 were recruited in a German trauma center. All received a standardized interview. In 21% (84/399) of all patients, osteoporosis was diagnosed prior to current admission. 34% (136/399) suffered a prior risk-fracture after age of 50. Of these, only 54% (73/136) reported about following dual-energy X-ray absorptiometry (DXA) to test for decreased bone-marrow-density with positive results in 68% (50/73). 38% (19/50) of these patients with fragility fractures and prior osteoporosis diagnosis received anti-osteoporotic medication. 66% (263/399) of all patients had no prior risk-fracture and were tested for osteoporosis by DXA in 36% (95/263), leading to positive results in 34% (32/95). 44% (14/32) of these patients received anti-osteoporotic medication. Applying FRAX, 33% of all patients showed a calculated 10-year-risk >20% for suffering a major osteoporotic fracture. 61% (83/136) of patients with a prior fracture had a 10-year-risk >20% of which 47% (39/83) patients received no prior DXA. Although guidelines recommend diagnosis and treatment of patients with low-energy fractures, opportunity for early treatment following risk fractures seems rarely used. Expedient risk assessment is necessary to indicate further diagnostics and therapy of osteoporosis to ensure adequate and efficient treatment for osteoporotic fractures. Public Library of Science 2018-11-12 /pmc/articles/PMC6231904/ /pubmed/30418992 http://dx.doi.org/10.1371/journal.pone.0207122 Text en © 2018 Rausch et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Rausch, Valentin
Schwarzer, Andreas
Dietrich, Johannes W.
Kaisler, Miriam
Seybold, Dominik
Vollert, Jan
Schildhauer, Thomas A.
Maier, Christoph
We miss the opportunity: Pretreament of osteoporosis in a German trauma center
title We miss the opportunity: Pretreament of osteoporosis in a German trauma center
title_full We miss the opportunity: Pretreament of osteoporosis in a German trauma center
title_fullStr We miss the opportunity: Pretreament of osteoporosis in a German trauma center
title_full_unstemmed We miss the opportunity: Pretreament of osteoporosis in a German trauma center
title_short We miss the opportunity: Pretreament of osteoporosis in a German trauma center
title_sort we miss the opportunity: pretreament of osteoporosis in a german trauma center
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231904/
https://www.ncbi.nlm.nih.gov/pubmed/30418992
http://dx.doi.org/10.1371/journal.pone.0207122
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