Cytomegalovirus Hemorrhagic Cystitis in a Malignant Glioma Patient Treated with Temozolomide

Temozolomide, a key drug in the treatment of malignant glioma, can cause profound lymphopenia and various opportunistic infectious diseases. A 79-year-old woman with anaplastic oligodendroglioma developed a fever and gross hematuria after 8 weeks of standard radiotherapy with concomitant temozolomid...

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Autores principales: Furukawa, Ryutaro, Homma, Hirokuni, Inoue, Tomohiro, Horiuchi, Hajime, Usui, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232021/
https://www.ncbi.nlm.nih.gov/pubmed/29780148
http://dx.doi.org/10.2169/internalmedicine.1005-18
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author Furukawa, Ryutaro
Homma, Hirokuni
Inoue, Tomohiro
Horiuchi, Hajime
Usui, Kazuhiro
author_facet Furukawa, Ryutaro
Homma, Hirokuni
Inoue, Tomohiro
Horiuchi, Hajime
Usui, Kazuhiro
author_sort Furukawa, Ryutaro
collection PubMed
description Temozolomide, a key drug in the treatment of malignant glioma, can cause profound lymphopenia and various opportunistic infectious diseases. A 79-year-old woman with anaplastic oligodendroglioma developed a fever and gross hematuria after 8 weeks of standard radiotherapy with concomitant temozolomide treatment. A cytomegalovirus (CMV) antigen test for pp65 antigenemia was positive (137 cells per 75,800 leukocytes), and the findings from a urine cytology test were consistent with CMV-induced hemorrhagic cystitis. She was treated with ganciclovir, and her condition improved. CMV monitoring is needed when patients develop symptoms related to opportunistic infections during temozolomide treatment for malignant glioma.
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spelling pubmed-62320212018-11-13 Cytomegalovirus Hemorrhagic Cystitis in a Malignant Glioma Patient Treated with Temozolomide Furukawa, Ryutaro Homma, Hirokuni Inoue, Tomohiro Horiuchi, Hajime Usui, Kazuhiro Intern Med Case Report Temozolomide, a key drug in the treatment of malignant glioma, can cause profound lymphopenia and various opportunistic infectious diseases. A 79-year-old woman with anaplastic oligodendroglioma developed a fever and gross hematuria after 8 weeks of standard radiotherapy with concomitant temozolomide treatment. A cytomegalovirus (CMV) antigen test for pp65 antigenemia was positive (137 cells per 75,800 leukocytes), and the findings from a urine cytology test were consistent with CMV-induced hemorrhagic cystitis. She was treated with ganciclovir, and her condition improved. CMV monitoring is needed when patients develop symptoms related to opportunistic infections during temozolomide treatment for malignant glioma. The Japanese Society of Internal Medicine 2018-05-18 2018-10-15 /pmc/articles/PMC6232021/ /pubmed/29780148 http://dx.doi.org/10.2169/internalmedicine.1005-18 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Furukawa, Ryutaro
Homma, Hirokuni
Inoue, Tomohiro
Horiuchi, Hajime
Usui, Kazuhiro
Cytomegalovirus Hemorrhagic Cystitis in a Malignant Glioma Patient Treated with Temozolomide
title Cytomegalovirus Hemorrhagic Cystitis in a Malignant Glioma Patient Treated with Temozolomide
title_full Cytomegalovirus Hemorrhagic Cystitis in a Malignant Glioma Patient Treated with Temozolomide
title_fullStr Cytomegalovirus Hemorrhagic Cystitis in a Malignant Glioma Patient Treated with Temozolomide
title_full_unstemmed Cytomegalovirus Hemorrhagic Cystitis in a Malignant Glioma Patient Treated with Temozolomide
title_short Cytomegalovirus Hemorrhagic Cystitis in a Malignant Glioma Patient Treated with Temozolomide
title_sort cytomegalovirus hemorrhagic cystitis in a malignant glioma patient treated with temozolomide
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232021/
https://www.ncbi.nlm.nih.gov/pubmed/29780148
http://dx.doi.org/10.2169/internalmedicine.1005-18
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