HIV Dementia with a Decreased Cardiac (123)I-metaiodobenzylguanidine Uptake Masquerading as Dementia with Lewy Bodies

Cardiac (123)I-metaiodobenzylguanidine (MIBG) scintigraphy is a promising biomarker for dementia with Lewy bodies (DLB). However, we experienced a patient with cognitive decline, parkinsonism, and a decreased MIBG uptake who turned out to have HIV dementia. Normal dopamine transporter single-photon...

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Detalles Bibliográficos
Autores principales: Kurihara, Masanori, Sasaki, Takuya, Ishiura, Hiroyuki, Tsuji, Shoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232034/
https://www.ncbi.nlm.nih.gov/pubmed/29780124
http://dx.doi.org/10.2169/internalmedicine.0876-18
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author Kurihara, Masanori
Sasaki, Takuya
Ishiura, Hiroyuki
Tsuji, Shoji
author_facet Kurihara, Masanori
Sasaki, Takuya
Ishiura, Hiroyuki
Tsuji, Shoji
author_sort Kurihara, Masanori
collection PubMed
description Cardiac (123)I-metaiodobenzylguanidine (MIBG) scintigraphy is a promising biomarker for dementia with Lewy bodies (DLB). However, we experienced a patient with cognitive decline, parkinsonism, and a decreased MIBG uptake who turned out to have HIV dementia. Normal dopamine transporter single-photon emission computed tomography reduced the possibility of comorbid Lewy body pathology causing the patient’s parkinsonism. The decreased MIBG uptake was most likely due to postganglionic sympathetic nerve denervation, which can also be caused by HIV. This case further emphasizes the importance of excluding other causes of autonomic neuropathy, including HIV infection, before interpreting MIBG scans.
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spelling pubmed-62320342018-11-13 HIV Dementia with a Decreased Cardiac (123)I-metaiodobenzylguanidine Uptake Masquerading as Dementia with Lewy Bodies Kurihara, Masanori Sasaki, Takuya Ishiura, Hiroyuki Tsuji, Shoji Intern Med Case Report Cardiac (123)I-metaiodobenzylguanidine (MIBG) scintigraphy is a promising biomarker for dementia with Lewy bodies (DLB). However, we experienced a patient with cognitive decline, parkinsonism, and a decreased MIBG uptake who turned out to have HIV dementia. Normal dopamine transporter single-photon emission computed tomography reduced the possibility of comorbid Lewy body pathology causing the patient’s parkinsonism. The decreased MIBG uptake was most likely due to postganglionic sympathetic nerve denervation, which can also be caused by HIV. This case further emphasizes the importance of excluding other causes of autonomic neuropathy, including HIV infection, before interpreting MIBG scans. The Japanese Society of Internal Medicine 2018-05-18 2018-10-15 /pmc/articles/PMC6232034/ /pubmed/29780124 http://dx.doi.org/10.2169/internalmedicine.0876-18 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kurihara, Masanori
Sasaki, Takuya
Ishiura, Hiroyuki
Tsuji, Shoji
HIV Dementia with a Decreased Cardiac (123)I-metaiodobenzylguanidine Uptake Masquerading as Dementia with Lewy Bodies
title HIV Dementia with a Decreased Cardiac (123)I-metaiodobenzylguanidine Uptake Masquerading as Dementia with Lewy Bodies
title_full HIV Dementia with a Decreased Cardiac (123)I-metaiodobenzylguanidine Uptake Masquerading as Dementia with Lewy Bodies
title_fullStr HIV Dementia with a Decreased Cardiac (123)I-metaiodobenzylguanidine Uptake Masquerading as Dementia with Lewy Bodies
title_full_unstemmed HIV Dementia with a Decreased Cardiac (123)I-metaiodobenzylguanidine Uptake Masquerading as Dementia with Lewy Bodies
title_short HIV Dementia with a Decreased Cardiac (123)I-metaiodobenzylguanidine Uptake Masquerading as Dementia with Lewy Bodies
title_sort hiv dementia with a decreased cardiac (123)i-metaiodobenzylguanidine uptake masquerading as dementia with lewy bodies
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232034/
https://www.ncbi.nlm.nih.gov/pubmed/29780124
http://dx.doi.org/10.2169/internalmedicine.0876-18
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