Propylthiouracil-induced Otitis Media with Antineutrophil Cytoplasmic Antibody-associated Vasculitis

We herein report a case of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) induced by propylthiouracil (PTU). A 30-year-old Japanese woman with Graves’ disease, who was treated with PTU, reported with otitis media with sensorineural hearing loss bilaterally...

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Detalles Bibliográficos
Autores principales: Tanaka, Rika, Shimojima, Yasuhiro, Moteki, Hideaki, Kishida, Dai, Ueno, Ken-ichi, Sekijima, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232041/
https://www.ncbi.nlm.nih.gov/pubmed/29780146
http://dx.doi.org/10.2169/internalmedicine.0944-18
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author Tanaka, Rika
Shimojima, Yasuhiro
Moteki, Hideaki
Kishida, Dai
Ueno, Ken-ichi
Sekijima, Yoshiki
author_facet Tanaka, Rika
Shimojima, Yasuhiro
Moteki, Hideaki
Kishida, Dai
Ueno, Ken-ichi
Sekijima, Yoshiki
author_sort Tanaka, Rika
collection PubMed
description We herein report a case of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) induced by propylthiouracil (PTU). A 30-year-old Japanese woman with Graves’ disease, who was treated with PTU, reported with otitis media with sensorineural hearing loss bilaterally and trigeminal neuralgia on the left side, as well as elevated serum levels of myeloperoxidase-ANCA. Prior treatment with antibiotics was ineffective even after tympanostomy. However, clinical remission was immediately achieved after initiating prednisolone together with PTU withdrawal. These findings suggest that PTU therapy induces localized otological involvement as the concept of OMAAV.
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spelling pubmed-62320412018-11-13 Propylthiouracil-induced Otitis Media with Antineutrophil Cytoplasmic Antibody-associated Vasculitis Tanaka, Rika Shimojima, Yasuhiro Moteki, Hideaki Kishida, Dai Ueno, Ken-ichi Sekijima, Yoshiki Intern Med Case Report We herein report a case of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) induced by propylthiouracil (PTU). A 30-year-old Japanese woman with Graves’ disease, who was treated with PTU, reported with otitis media with sensorineural hearing loss bilaterally and trigeminal neuralgia on the left side, as well as elevated serum levels of myeloperoxidase-ANCA. Prior treatment with antibiotics was ineffective even after tympanostomy. However, clinical remission was immediately achieved after initiating prednisolone together with PTU withdrawal. These findings suggest that PTU therapy induces localized otological involvement as the concept of OMAAV. The Japanese Society of Internal Medicine 2018-05-18 2018-10-15 /pmc/articles/PMC6232041/ /pubmed/29780146 http://dx.doi.org/10.2169/internalmedicine.0944-18 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Tanaka, Rika
Shimojima, Yasuhiro
Moteki, Hideaki
Kishida, Dai
Ueno, Ken-ichi
Sekijima, Yoshiki
Propylthiouracil-induced Otitis Media with Antineutrophil Cytoplasmic Antibody-associated Vasculitis
title Propylthiouracil-induced Otitis Media with Antineutrophil Cytoplasmic Antibody-associated Vasculitis
title_full Propylthiouracil-induced Otitis Media with Antineutrophil Cytoplasmic Antibody-associated Vasculitis
title_fullStr Propylthiouracil-induced Otitis Media with Antineutrophil Cytoplasmic Antibody-associated Vasculitis
title_full_unstemmed Propylthiouracil-induced Otitis Media with Antineutrophil Cytoplasmic Antibody-associated Vasculitis
title_short Propylthiouracil-induced Otitis Media with Antineutrophil Cytoplasmic Antibody-associated Vasculitis
title_sort propylthiouracil-induced otitis media with antineutrophil cytoplasmic antibody-associated vasculitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232041/
https://www.ncbi.nlm.nih.gov/pubmed/29780146
http://dx.doi.org/10.2169/internalmedicine.0944-18
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