Successful Treatment of IgA Vasculitis Complicated with Bowel Perforation and Crescentic Glomerulonephritis by Combination Therapy of Glucocorticoid, Cyclosporine and Factor XIII Replacement

We report the findings of an 18-year-old boy with immunoglobulin A vasculitis (IgAV) complicated with bowel perforation and nephritis. He presented with abdominal pain, arthralgia and palpable purpura. Massive proteinuria developed during his clinical course. The patient was treated successfully usi...

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Autores principales: Koshiba, Keiko, Muraoka, Sei, Nanki, Toshihiro, Komatsumoto, Satoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232042/
https://www.ncbi.nlm.nih.gov/pubmed/29877285
http://dx.doi.org/10.2169/internalmedicine.0931-18
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author Koshiba, Keiko
Muraoka, Sei
Nanki, Toshihiro
Komatsumoto, Satoru
author_facet Koshiba, Keiko
Muraoka, Sei
Nanki, Toshihiro
Komatsumoto, Satoru
author_sort Koshiba, Keiko
collection PubMed
description We report the findings of an 18-year-old boy with immunoglobulin A vasculitis (IgAV) complicated with bowel perforation and nephritis. He presented with abdominal pain, arthralgia and palpable purpura. Massive proteinuria developed during his clinical course. The patient was treated successfully using combination therapy of glucocorticoid (GC), cyclosporine (CYA) and factor XIII (F XIII) replacement. A standard treatment strategy for severe IgAV patients has not been established due to its rarity. Combination therapy using GC, CYA and F XIII replacement should be considered for severe IgAV patients.
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spelling pubmed-62320422018-11-13 Successful Treatment of IgA Vasculitis Complicated with Bowel Perforation and Crescentic Glomerulonephritis by Combination Therapy of Glucocorticoid, Cyclosporine and Factor XIII Replacement Koshiba, Keiko Muraoka, Sei Nanki, Toshihiro Komatsumoto, Satoru Intern Med Case Report We report the findings of an 18-year-old boy with immunoglobulin A vasculitis (IgAV) complicated with bowel perforation and nephritis. He presented with abdominal pain, arthralgia and palpable purpura. Massive proteinuria developed during his clinical course. The patient was treated successfully using combination therapy of glucocorticoid (GC), cyclosporine (CYA) and factor XIII (F XIII) replacement. A standard treatment strategy for severe IgAV patients has not been established due to its rarity. Combination therapy using GC, CYA and F XIII replacement should be considered for severe IgAV patients. The Japanese Society of Internal Medicine 2018-06-06 2018-10-15 /pmc/articles/PMC6232042/ /pubmed/29877285 http://dx.doi.org/10.2169/internalmedicine.0931-18 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Koshiba, Keiko
Muraoka, Sei
Nanki, Toshihiro
Komatsumoto, Satoru
Successful Treatment of IgA Vasculitis Complicated with Bowel Perforation and Crescentic Glomerulonephritis by Combination Therapy of Glucocorticoid, Cyclosporine and Factor XIII Replacement
title Successful Treatment of IgA Vasculitis Complicated with Bowel Perforation and Crescentic Glomerulonephritis by Combination Therapy of Glucocorticoid, Cyclosporine and Factor XIII Replacement
title_full Successful Treatment of IgA Vasculitis Complicated with Bowel Perforation and Crescentic Glomerulonephritis by Combination Therapy of Glucocorticoid, Cyclosporine and Factor XIII Replacement
title_fullStr Successful Treatment of IgA Vasculitis Complicated with Bowel Perforation and Crescentic Glomerulonephritis by Combination Therapy of Glucocorticoid, Cyclosporine and Factor XIII Replacement
title_full_unstemmed Successful Treatment of IgA Vasculitis Complicated with Bowel Perforation and Crescentic Glomerulonephritis by Combination Therapy of Glucocorticoid, Cyclosporine and Factor XIII Replacement
title_short Successful Treatment of IgA Vasculitis Complicated with Bowel Perforation and Crescentic Glomerulonephritis by Combination Therapy of Glucocorticoid, Cyclosporine and Factor XIII Replacement
title_sort successful treatment of iga vasculitis complicated with bowel perforation and crescentic glomerulonephritis by combination therapy of glucocorticoid, cyclosporine and factor xiii replacement
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232042/
https://www.ncbi.nlm.nih.gov/pubmed/29877285
http://dx.doi.org/10.2169/internalmedicine.0931-18
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