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Elevated allostatic load early in the course of schizophrenia
Stress plays a significant role in schizophrenia from disease onset to exacerbation of psychotic symptoms. Allostatic load (AL) is a measure of cumulative stress to the organism. This study is an extension of our previous work on AL and its relationship to brain structures. Here, we further determin...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232085/ https://www.ncbi.nlm.nih.gov/pubmed/30420620 http://dx.doi.org/10.1038/s41398-018-0299-z |
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author | Savransky, Anya Chiappelli, Joshua Fisseha, Feven Wisner, Krista M. Xiaoming, Du Mirmomen, S. Milad Jones, Aaron D. Adhikari, Bhim M. Bruce, Heather A. Rowland, Laura M. Hong, L. Elliot |
author_facet | Savransky, Anya Chiappelli, Joshua Fisseha, Feven Wisner, Krista M. Xiaoming, Du Mirmomen, S. Milad Jones, Aaron D. Adhikari, Bhim M. Bruce, Heather A. Rowland, Laura M. Hong, L. Elliot |
author_sort | Savransky, Anya |
collection | PubMed |
description | Stress plays a significant role in schizophrenia from disease onset to exacerbation of psychotic symptoms. Allostatic load (AL) is a measure of cumulative stress to the organism. This study is an extension of our previous work on AL and its relationship to brain structures. Here, we further determined whether elevated AL is a function of illness chronicity, or if it is already present early in the course of schizophrenia. AL was compared in schizophrenia patients early in the illness (within 5 years of disease onset), patients with chronic schizophrenia (more than 5 years of illness), and two groups of healthy controls that were age-and sex-matched to the two patient groups. This work is presented with an expanded sample and includes about two-thirds of the participants who were previously reported. We found that patients with early psychosis had significantly elevated AL score compared with their age-matched controls (p = 0.005). Chronic course patients also had elevated AL compared with age-matched controls (p = 0.003). Immune and stress hormone AL subcomponents were nominally higher in early-stage patients compared with controls (p = 0.005 and 0.04, respectively). Greater AL was also associated with more severe positive psychotic symptoms in early-stage patients (r = 0.54, p = 0.01). Elevated levels of allostatic load are already present in the early years of the schizophrenia illness, particularly in patients with more severe psychotic symptoms. AL may be a useful evaluation for the need of early intervention on psychosomatic comorbidity. |
format | Online Article Text |
id | pubmed-6232085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-62320852018-11-19 Elevated allostatic load early in the course of schizophrenia Savransky, Anya Chiappelli, Joshua Fisseha, Feven Wisner, Krista M. Xiaoming, Du Mirmomen, S. Milad Jones, Aaron D. Adhikari, Bhim M. Bruce, Heather A. Rowland, Laura M. Hong, L. Elliot Transl Psychiatry Article Stress plays a significant role in schizophrenia from disease onset to exacerbation of psychotic symptoms. Allostatic load (AL) is a measure of cumulative stress to the organism. This study is an extension of our previous work on AL and its relationship to brain structures. Here, we further determined whether elevated AL is a function of illness chronicity, or if it is already present early in the course of schizophrenia. AL was compared in schizophrenia patients early in the illness (within 5 years of disease onset), patients with chronic schizophrenia (more than 5 years of illness), and two groups of healthy controls that were age-and sex-matched to the two patient groups. This work is presented with an expanded sample and includes about two-thirds of the participants who were previously reported. We found that patients with early psychosis had significantly elevated AL score compared with their age-matched controls (p = 0.005). Chronic course patients also had elevated AL compared with age-matched controls (p = 0.003). Immune and stress hormone AL subcomponents were nominally higher in early-stage patients compared with controls (p = 0.005 and 0.04, respectively). Greater AL was also associated with more severe positive psychotic symptoms in early-stage patients (r = 0.54, p = 0.01). Elevated levels of allostatic load are already present in the early years of the schizophrenia illness, particularly in patients with more severe psychotic symptoms. AL may be a useful evaluation for the need of early intervention on psychosomatic comorbidity. Nature Publishing Group UK 2018-11-12 /pmc/articles/PMC6232085/ /pubmed/30420620 http://dx.doi.org/10.1038/s41398-018-0299-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Savransky, Anya Chiappelli, Joshua Fisseha, Feven Wisner, Krista M. Xiaoming, Du Mirmomen, S. Milad Jones, Aaron D. Adhikari, Bhim M. Bruce, Heather A. Rowland, Laura M. Hong, L. Elliot Elevated allostatic load early in the course of schizophrenia |
title | Elevated allostatic load early in the course of schizophrenia |
title_full | Elevated allostatic load early in the course of schizophrenia |
title_fullStr | Elevated allostatic load early in the course of schizophrenia |
title_full_unstemmed | Elevated allostatic load early in the course of schizophrenia |
title_short | Elevated allostatic load early in the course of schizophrenia |
title_sort | elevated allostatic load early in the course of schizophrenia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232085/ https://www.ncbi.nlm.nih.gov/pubmed/30420620 http://dx.doi.org/10.1038/s41398-018-0299-z |
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