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Correlation between genomic index lesions and mpMRI and (68)Ga-PSMA-PET/CT imaging features in primary prostate cancer

Magnetic resonance imaging (MRI) and prostate specific membrane antigen (PSMA)- positron emission tomography (PET)/computed tomography (CT)-imaging of prostate cancer (PCa) are emerging techniques to assess the presence of significant disease and tumor progression. It is not known, however, whether...

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Autores principales: Kesch, Claudia, Radtke, Jan-Philipp, Wintsche, Axel, Wiesenfarth, Manuel, Luttje, Mariska, Gasch, Claudia, Dieffenbacher, Svenja, Pecqueux, Carine, Teber, Dogu, Hatiboglu, Gencay, Nyarangi-Dix, Joanne, Simpfendörfer, Tobias, Schönberg, Gita, Dimitrakopoulou-Strauss, Antonia, Freitag, Martin, Duensing, Anette, Grüllich, Carsten, Jäger, Dirk, Götz, Michael, Grabe, Niels, Schweiger, Michal-Ruth, Pahernik, Sascha, Perner, Sven, Herpel, Esther, Roth, Wilfried, Wieczorek, Kathrin, Maier-Hein, Klaus, Debus, Jürgen, Haberkorn, Uwe, Giesel, Frederik, Galle, Jörg, Hadaschik, Boris, Schlemmer, Heinz-Peter, Hohenfellner, Markus, Bonekamp, David, Sültmann, Holger, Duensing, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232089/
https://www.ncbi.nlm.nih.gov/pubmed/30420756
http://dx.doi.org/10.1038/s41598-018-35058-3
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author Kesch, Claudia
Radtke, Jan-Philipp
Wintsche, Axel
Wiesenfarth, Manuel
Luttje, Mariska
Gasch, Claudia
Dieffenbacher, Svenja
Pecqueux, Carine
Teber, Dogu
Hatiboglu, Gencay
Nyarangi-Dix, Joanne
Simpfendörfer, Tobias
Schönberg, Gita
Dimitrakopoulou-Strauss, Antonia
Freitag, Martin
Duensing, Anette
Grüllich, Carsten
Jäger, Dirk
Götz, Michael
Grabe, Niels
Schweiger, Michal-Ruth
Pahernik, Sascha
Perner, Sven
Herpel, Esther
Roth, Wilfried
Wieczorek, Kathrin
Maier-Hein, Klaus
Debus, Jürgen
Haberkorn, Uwe
Giesel, Frederik
Galle, Jörg
Hadaschik, Boris
Schlemmer, Heinz-Peter
Hohenfellner, Markus
Bonekamp, David
Sültmann, Holger
Duensing, Stefan
author_facet Kesch, Claudia
Radtke, Jan-Philipp
Wintsche, Axel
Wiesenfarth, Manuel
Luttje, Mariska
Gasch, Claudia
Dieffenbacher, Svenja
Pecqueux, Carine
Teber, Dogu
Hatiboglu, Gencay
Nyarangi-Dix, Joanne
Simpfendörfer, Tobias
Schönberg, Gita
Dimitrakopoulou-Strauss, Antonia
Freitag, Martin
Duensing, Anette
Grüllich, Carsten
Jäger, Dirk
Götz, Michael
Grabe, Niels
Schweiger, Michal-Ruth
Pahernik, Sascha
Perner, Sven
Herpel, Esther
Roth, Wilfried
Wieczorek, Kathrin
Maier-Hein, Klaus
Debus, Jürgen
Haberkorn, Uwe
Giesel, Frederik
Galle, Jörg
Hadaschik, Boris
Schlemmer, Heinz-Peter
Hohenfellner, Markus
Bonekamp, David
Sültmann, Holger
Duensing, Stefan
author_sort Kesch, Claudia
collection PubMed
description Magnetic resonance imaging (MRI) and prostate specific membrane antigen (PSMA)- positron emission tomography (PET)/computed tomography (CT)-imaging of prostate cancer (PCa) are emerging techniques to assess the presence of significant disease and tumor progression. It is not known, however, whether and to what extent lesions detected by these imaging techniques correlate with genomic features of PCa. The aim of this study was therefore to define a genomic index lesion based on chromosomal copy number alterations (CNAs) as marker for tumor aggressiveness in prostate biopsies in direct correlation to multiparametric (mp) MRI and (68)Ga-PSMA-PET/CT imaging features. CNA profiles of 46 biopsies from five consecutive patients with clinically high-risk PCa were obtained from radiologically suspicious and unsuspicious areas. All patients underwent mpMRI, MRI/TRUS-fusion biopsy, (68)Ga-PSMA-PET/CT and a radical prostatectomy. CNAs were directly correlated to imaging features and radiogenomic analyses were performed. Highly significant CNAs (≥10 Mbp) were found in 22 of 46 biopsies. Chromosome 8p, 13q and 5q losses were the most common findings. There was an strong correspondence between the radiologic and the genomic index lesions. The radiogenomic analyses suggest the feasibility of developing radiologic signatures that can distinguish between genomically more or less aggressive lesions. In conclusion, imaging features of mpMRI and (68)Ga-PSMA-PET/CT can guide to the genomically most aggressive lesion of a PCa. Radiogenomics may help to better differentiate between indolent and aggressive PCa in the future.
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spelling pubmed-62320892018-11-28 Correlation between genomic index lesions and mpMRI and (68)Ga-PSMA-PET/CT imaging features in primary prostate cancer Kesch, Claudia Radtke, Jan-Philipp Wintsche, Axel Wiesenfarth, Manuel Luttje, Mariska Gasch, Claudia Dieffenbacher, Svenja Pecqueux, Carine Teber, Dogu Hatiboglu, Gencay Nyarangi-Dix, Joanne Simpfendörfer, Tobias Schönberg, Gita Dimitrakopoulou-Strauss, Antonia Freitag, Martin Duensing, Anette Grüllich, Carsten Jäger, Dirk Götz, Michael Grabe, Niels Schweiger, Michal-Ruth Pahernik, Sascha Perner, Sven Herpel, Esther Roth, Wilfried Wieczorek, Kathrin Maier-Hein, Klaus Debus, Jürgen Haberkorn, Uwe Giesel, Frederik Galle, Jörg Hadaschik, Boris Schlemmer, Heinz-Peter Hohenfellner, Markus Bonekamp, David Sültmann, Holger Duensing, Stefan Sci Rep Article Magnetic resonance imaging (MRI) and prostate specific membrane antigen (PSMA)- positron emission tomography (PET)/computed tomography (CT)-imaging of prostate cancer (PCa) are emerging techniques to assess the presence of significant disease and tumor progression. It is not known, however, whether and to what extent lesions detected by these imaging techniques correlate with genomic features of PCa. The aim of this study was therefore to define a genomic index lesion based on chromosomal copy number alterations (CNAs) as marker for tumor aggressiveness in prostate biopsies in direct correlation to multiparametric (mp) MRI and (68)Ga-PSMA-PET/CT imaging features. CNA profiles of 46 biopsies from five consecutive patients with clinically high-risk PCa were obtained from radiologically suspicious and unsuspicious areas. All patients underwent mpMRI, MRI/TRUS-fusion biopsy, (68)Ga-PSMA-PET/CT and a radical prostatectomy. CNAs were directly correlated to imaging features and radiogenomic analyses were performed. Highly significant CNAs (≥10 Mbp) were found in 22 of 46 biopsies. Chromosome 8p, 13q and 5q losses were the most common findings. There was an strong correspondence between the radiologic and the genomic index lesions. The radiogenomic analyses suggest the feasibility of developing radiologic signatures that can distinguish between genomically more or less aggressive lesions. In conclusion, imaging features of mpMRI and (68)Ga-PSMA-PET/CT can guide to the genomically most aggressive lesion of a PCa. Radiogenomics may help to better differentiate between indolent and aggressive PCa in the future. Nature Publishing Group UK 2018-11-12 /pmc/articles/PMC6232089/ /pubmed/30420756 http://dx.doi.org/10.1038/s41598-018-35058-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kesch, Claudia
Radtke, Jan-Philipp
Wintsche, Axel
Wiesenfarth, Manuel
Luttje, Mariska
Gasch, Claudia
Dieffenbacher, Svenja
Pecqueux, Carine
Teber, Dogu
Hatiboglu, Gencay
Nyarangi-Dix, Joanne
Simpfendörfer, Tobias
Schönberg, Gita
Dimitrakopoulou-Strauss, Antonia
Freitag, Martin
Duensing, Anette
Grüllich, Carsten
Jäger, Dirk
Götz, Michael
Grabe, Niels
Schweiger, Michal-Ruth
Pahernik, Sascha
Perner, Sven
Herpel, Esther
Roth, Wilfried
Wieczorek, Kathrin
Maier-Hein, Klaus
Debus, Jürgen
Haberkorn, Uwe
Giesel, Frederik
Galle, Jörg
Hadaschik, Boris
Schlemmer, Heinz-Peter
Hohenfellner, Markus
Bonekamp, David
Sültmann, Holger
Duensing, Stefan
Correlation between genomic index lesions and mpMRI and (68)Ga-PSMA-PET/CT imaging features in primary prostate cancer
title Correlation between genomic index lesions and mpMRI and (68)Ga-PSMA-PET/CT imaging features in primary prostate cancer
title_full Correlation between genomic index lesions and mpMRI and (68)Ga-PSMA-PET/CT imaging features in primary prostate cancer
title_fullStr Correlation between genomic index lesions and mpMRI and (68)Ga-PSMA-PET/CT imaging features in primary prostate cancer
title_full_unstemmed Correlation between genomic index lesions and mpMRI and (68)Ga-PSMA-PET/CT imaging features in primary prostate cancer
title_short Correlation between genomic index lesions and mpMRI and (68)Ga-PSMA-PET/CT imaging features in primary prostate cancer
title_sort correlation between genomic index lesions and mpmri and (68)ga-psma-pet/ct imaging features in primary prostate cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232089/
https://www.ncbi.nlm.nih.gov/pubmed/30420756
http://dx.doi.org/10.1038/s41598-018-35058-3
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