Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage

Leucine-rich repeat kinase 2 (LRRK2), originally identified as a causative genetic factor in Parkinson’s disease, is now associated with a number of pathologies. Here, we show that brain injury induces a robust expression of endogenous LRRK2 and suggest a role of LRRK2 after injury. We found that va...

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Detalles Bibliográficos
Autores principales: Bae, Yun-Hee, Joo, Hyejin, Bae, Jinhyun, Hyeon, Seung Jae, Her, Song, Ko, Eunhwa, Choi, Hwan Geun, Ryu, Hoon, Hur, Eun-Mi, Bu, Youngmin, Lee, Byoung Dae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232134/
https://www.ncbi.nlm.nih.gov/pubmed/30420654
http://dx.doi.org/10.1038/s41419-018-1180-y

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