Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

Chromothripsis and chromoanasynthesis are catastrophic events leading to clustered genomic rearrangements. Whole-genome sequencing revealed frequent complex genomic rearrangements (n = 16/26) in brain tumors developing in mice deficient for factors involved in homologous-recombination-repair or non-...

Descripción completa

Detalles Bibliográficos
Autores principales: Ratnaparkhe, Manasi, Wong, John K. L., Wei, Pei-Chi, Hlevnjak, Mario, Kolb, Thorsten, Simovic, Milena, Haag, Daniel, Paul, Yashna, Devens, Frauke, Northcott, Paul, Jones, David T. W., Kool, Marcel, Jauch, Anna, Pastorczak, Agata, Mlynarski, Wojciech, Korshunov, Andrey, Kumar, Rajiv, Downing, Susanna M., Pfister, Stefan M., Zapatka, Marc, McKinnon, Peter J., Alt, Frederick W., Lichter, Peter, Ernst, Aurélie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232171/
https://www.ncbi.nlm.nih.gov/pubmed/30420702
http://dx.doi.org/10.1038/s41467-018-06925-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232171/
https://www.ncbi.nlm.nih.gov/pubmed/30420702
http://dx.doi.org/10.1038/s41467-018-06925-4

Ejemplares similares