Cargando…

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

Chromothripsis and chromoanasynthesis are catastrophic events leading to clustered genomic rearrangements. Whole-genome sequencing revealed frequent complex genomic rearrangements (n = 16/26) in brain tumors developing in mice deficient for factors involved in homologous-recombination-repair or non-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ratnaparkhe, Manasi, Wong, John K. L., Wei, Pei-Chi, Hlevnjak, Mario, Kolb, Thorsten, Simovic, Milena, Haag, Daniel, Paul, Yashna, Devens, Frauke, Northcott, Paul, Jones, David T. W., Kool, Marcel, Jauch, Anna, Pastorczak, Agata, Mlynarski, Wojciech, Korshunov, Andrey, Kumar, Rajiv, Downing, Susanna M., Pfister, Stefan M., Zapatka, Marc, McKinnon, Peter J., Alt, Frederick W., Lichter, Peter, Ernst, Aurélie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232171/ https://www.ncbi.nlm.nih.gov/pubmed/30420702 http://dx.doi.org/10.1038/s41467-018-06925-4

Ejemplares similares

Coverage Bias and Sensitivity of Variant Calling for Four Whole-genome Sequencing Technologies
por: Rieber, Nora, et al.
Publicado: (2013)

A novel cloning strategy for one-step assembly of multiplex CRISPR vectors
por: Zuckermann, Marc, et al.
Publicado: (2018)

Association of mutation signature effectuating processes with mutation hotspots in driver genes and non-coding regions
por: Wong, John K. L., et al.
Publicado: (2022)

Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors
por: Lee, Youngsoo, et al.
Publicado: (2012)

Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays
por: Hovestadt, Volker, et al.
Publicado: (2013)

Longitudinal analyses of CLL in mice identify leukemia-related clonal changes including a Myc gain predicting poor outcome in patients
por: Öztürk, Selcen, et al.
Publicado: (2021)

Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling
por: Zuckermann, Marc, et al.
Publicado: (2015)

Update on molecular and genetic alterations in adult medulloblastoma
por: Kool, Marcel, et al.
Publicado: (2012)

Molecular subgroups of medulloblastoma: the current consensus
por: Taylor, Michael D., et al.
Publicado: (2011)

LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR)
por: Korshunov, Andrey, et al.
Publicado: (2012)

confFuse: High-Confidence Fusion Gene Detection across Tumor Entities
por: Huang, Zhiqin, et al.
Publicado: (2017)

Genome-wide identification of translationally inhibited and degraded miR-155 targets using RNA-interacting protein-IP
por: Meier, Jan, et al.
Publicado: (2013)

Capture and Amplification by Tailing and Switching (CATS): An ultrasensitive ligation-independent method for generation of DNA libraries for deep sequencing from picogram amounts of DNA and RNA
por: Turchinovich, Andrey, et al.
Publicado: (2014)

ETMR: a tumor entity in its infancy
por: Lambo, Sander, et al.
Publicado: (2020)

CITED4 gene silencing in colorectal cancer cells modulates adherens/tight junction gene expression and reduces cell proliferation
por: Rogers, Michael A., et al.
Publicado: (2015)

Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort
por: Pietsch, Torsten, et al.
Publicado: (2014)

Germline 3p22.1 microdeletion encompassing RPSA gene is an ultra-rare cause of isolated asplenia
por: Oszer, Aleksandra, et al.
Publicado: (2021)

Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells
por: Kawauchi, D, et al.
Publicado: (2017)

ICGC PedBrain - dissecting the genomic complexity underlying medulloblastoma using whole-genome sequencing
por: Jäger, Natalie, et al.
Publicado: (2012)

Low-dose Actinomycin-D treatment re-establishes the tumoursuppressive function of P53 in RELA-positive ependymoma
por: Tzaridis, Theophilos, et al.
Publicado: (2016)

Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity
por: Korshunov, Andrey, et al.
Publicado: (2013)

Carbon ion radiotherapy eradicates medulloblastomas with chromothripsis in an orthotopic Li-Fraumeni patient-derived mouse model
por: Simovic, Milena, et al.
Publicado: (2021)

Genome integrity and disease prevention in the nervous system
por: McKinnon, Peter J.
Publicado: (2017)

An introduction to catastrophe theory
por: Saunders, Peter Timothy
Publicado: (1980)

Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme
por: Feng, Weijun, et al.
Publicado: (2017)

Influence of genomic variation in FTO at 16q12.2, MC4R at 18q22 and NRXN3 at 14q31 genes on breast cancer risk
por: Kusinska, Renata, et al.
Publicado: (2011)

scSNPdemux: a sensitive demultiplexing pipeline using single nucleotide polymorphisms for improved pooled single-cell RNA sequencing analysis
por: Wong, John K. L., et al.
Publicado: (2023)

Gene Prioritization by Integrated Analysis of Protein Structural and Network Topological Properties for the Protein-Protein Interaction Network of Neurological Disorders
por: Paul, Yashna, et al.
Publicado: (2016)

Expression analysis of imbalanced genes in prostate carcinoma using tissue microarrays
por: Prowatke, I, et al.
Publicado: (2007)

Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples
por: Northcott, Paul A., et al.
Publicado: (2011)

Impact of mTOR expression on clinical outcome in paediatric patients with B-cell acute lymphoblastic leukaemia – preliminary report
por: Ulińska, Edyta, et al.
Publicado: (2016)

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas
por: Kool, Marcel, et al.
Publicado: (2012)

Novel FANCA mutation in the first fully-diagnosed patient with Fanconi anemia in Polish population – case report
por: Repczynska, Anna, et al.
Publicado: (2020)

MLPA as a complementary tool for diagnosis of chromosome 21 aberrations in childhood BCP-ALL
por: Wrona, Ewa, et al.
Publicado: (2019)

The WIP1 Oncogene Promotes Progression and Invasion of Aggressive Medulloblastoma Variants
por: Buss, Meghan C., et al.
Publicado: (2014)

Catastrophic Cervical Spine Injuries in Contact Sports
por: Hutton, Michael James, et al.
Publicado: (2016)

Ovarian carcinoma in children with constitutional mutation of SMARCA4: single-family report and literature review
por: Pastorczak, Agata, et al.
Publicado: (2021)

Structural Stability, the Theory of Catastrophes, and Applications in the Sciences
por: Hilton, Peter
Publicado: (1976)

Strength Gains as a Result of Brief, Infrequent Resistance Exercise in Older Adults
por: Fisher, James, et al.
Publicado: (2014)

A cell-based model system links chromothripsis with hyperploidy
por: Mardin, Balca R, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_bdn9dq9fkdfbjbu5e4logp9ilo