Immunohistochemical expression of thymidylate synthase and prognosis in gastric cancer patients submitted to fluoropyrimidine-based chemotherapy

OBJECTIVE: Adjuvant chemotherapy with 5-fluorouracil (5-FU) has been widely used in gastric cancer (GC) patients to prevent relapse after curative resection. 5-FU acts by inhibiting thymidylate synthase (TS), and high levels of TS correlate with resistance to treatment with fluoropyrimidines. The ai...

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Detalles Bibliográficos
Autores principales: Pereira, Marina Alessandra, Ramos, Marcus Fernando Kodama Pertille, Dias, Andre Roncon, Faraj, Sheila Friedrich, Cirqueira, Cinthya dos Santos, de Mello, Evandro Sobroza, Zilberstein, Bruno, Alves, Venancio Avancini Ferreira, Ribeiro Jr., Ulysses
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232357/
https://www.ncbi.nlm.nih.gov/pubmed/30510364
http://dx.doi.org/10.21147/j.issn.1000-9604.2018.05.06

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