Metabolism and Bioactivation of Corynoline With Characterization of the Glutathione/Cysteine Conjugate and Evaluation of Its Hepatotoxicity in Mice

Corynoline (CRL), an isoquinoline alkaloid, is the major constituent derived from Corydalis bungeana Herba, which is a well-known Chinese herbal medicine widely used in many prescriptions. The purpose of this study was to comprehensively investigate the metabolism and bioactivation of CRL, and ident...

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Detalles Bibliográficos
Autores principales: Liu, Ruijuan, Zhou, Fang, He, He, Wei, Jingyao, Tian, Xin, Ding, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232370/
https://www.ncbi.nlm.nih.gov/pubmed/30459618
http://dx.doi.org/10.3389/fphar.2018.01264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232370/
https://www.ncbi.nlm.nih.gov/pubmed/30459618
http://dx.doi.org/10.3389/fphar.2018.01264

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