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Acrodermatitis chronica atrophicans: various faces of the late form of Lyme borreliosis

INTRODUCTION: Acrodermatitis chronica atrophicans (ACA) is probably the most common late and chronic manifestation of the Lyme borreliosis seen in European patients. AIM: To analyze epidemiological data, and to investigate the effects of treatment of patients with ACA. MATERIAL AND METHODS: Nine pat...

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Autores principales: Moniuszko-Malinowska, Anna, Czupryna, Piotr, Dunaj, Justyna, Pancewicz, Sławomir, Garkowski, Adam, Kondrusik, Maciej, Grygorczuk, Sambor, Zajkowska, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232541/
https://www.ncbi.nlm.nih.gov/pubmed/30429707
http://dx.doi.org/10.5114/ada.2018.77240
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author Moniuszko-Malinowska, Anna
Czupryna, Piotr
Dunaj, Justyna
Pancewicz, Sławomir
Garkowski, Adam
Kondrusik, Maciej
Grygorczuk, Sambor
Zajkowska, Joanna
author_facet Moniuszko-Malinowska, Anna
Czupryna, Piotr
Dunaj, Justyna
Pancewicz, Sławomir
Garkowski, Adam
Kondrusik, Maciej
Grygorczuk, Sambor
Zajkowska, Joanna
author_sort Moniuszko-Malinowska, Anna
collection PubMed
description INTRODUCTION: Acrodermatitis chronica atrophicans (ACA) is probably the most common late and chronic manifestation of the Lyme borreliosis seen in European patients. AIM: To analyze epidemiological data, and to investigate the effects of treatment of patients with ACA. MATERIAL AND METHODS: Nine patients were included in the study. All patients had serological examinations (ELISA and Western blot) and histopathological examination of the skin lesions performed. Eight patients had PCR in the skin biopsy performed. RESULTS: The duration of symptoms ranged from 2 months to 2 years. In 7 patients, skin lesions were located on lower limbs, in 2 patients – in a non-typical body area – abdomen. In 1 patient, scleroderma and in 3 patients, diabetes mellitus was diagnosed. Borrelia burgdorferi DNA was detected in 25% of the skin biopsy specimens. IgG anti-B. burgdorferi specific antibodies were present in serum of all patients (confirmed by Western blot). In all cases, the diagnosis was confirmed by histopathological examination. The response to ceftriaxone therapy varied. In 5 cases, the lesions resolved completely, in others they faded. CONCLUSIONS: Despite raising awareness of Lyme borreliosis, late forms of the disease such as ACA are still observed. Acrodermatitis chronica atrophicans skin lesions may be located in non-characteristic areas, e.g. abdominal skin. Symptoms are not irritating or painful, therefore patients do not seek medical help. The effect of antibiotic treatment varies.
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spelling pubmed-62325412018-11-14 Acrodermatitis chronica atrophicans: various faces of the late form of Lyme borreliosis Moniuszko-Malinowska, Anna Czupryna, Piotr Dunaj, Justyna Pancewicz, Sławomir Garkowski, Adam Kondrusik, Maciej Grygorczuk, Sambor Zajkowska, Joanna Postepy Dermatol Alergol Original Paper INTRODUCTION: Acrodermatitis chronica atrophicans (ACA) is probably the most common late and chronic manifestation of the Lyme borreliosis seen in European patients. AIM: To analyze epidemiological data, and to investigate the effects of treatment of patients with ACA. MATERIAL AND METHODS: Nine patients were included in the study. All patients had serological examinations (ELISA and Western blot) and histopathological examination of the skin lesions performed. Eight patients had PCR in the skin biopsy performed. RESULTS: The duration of symptoms ranged from 2 months to 2 years. In 7 patients, skin lesions were located on lower limbs, in 2 patients – in a non-typical body area – abdomen. In 1 patient, scleroderma and in 3 patients, diabetes mellitus was diagnosed. Borrelia burgdorferi DNA was detected in 25% of the skin biopsy specimens. IgG anti-B. burgdorferi specific antibodies were present in serum of all patients (confirmed by Western blot). In all cases, the diagnosis was confirmed by histopathological examination. The response to ceftriaxone therapy varied. In 5 cases, the lesions resolved completely, in others they faded. CONCLUSIONS: Despite raising awareness of Lyme borreliosis, late forms of the disease such as ACA are still observed. Acrodermatitis chronica atrophicans skin lesions may be located in non-characteristic areas, e.g. abdominal skin. Symptoms are not irritating or painful, therefore patients do not seek medical help. The effect of antibiotic treatment varies. Termedia Publishing House 2018-07-19 2018-10 /pmc/articles/PMC6232541/ /pubmed/30429707 http://dx.doi.org/10.5114/ada.2018.77240 Text en Copyright: © 2018 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Moniuszko-Malinowska, Anna
Czupryna, Piotr
Dunaj, Justyna
Pancewicz, Sławomir
Garkowski, Adam
Kondrusik, Maciej
Grygorczuk, Sambor
Zajkowska, Joanna
Acrodermatitis chronica atrophicans: various faces of the late form of Lyme borreliosis
title Acrodermatitis chronica atrophicans: various faces of the late form of Lyme borreliosis
title_full Acrodermatitis chronica atrophicans: various faces of the late form of Lyme borreliosis
title_fullStr Acrodermatitis chronica atrophicans: various faces of the late form of Lyme borreliosis
title_full_unstemmed Acrodermatitis chronica atrophicans: various faces of the late form of Lyme borreliosis
title_short Acrodermatitis chronica atrophicans: various faces of the late form of Lyme borreliosis
title_sort acrodermatitis chronica atrophicans: various faces of the late form of lyme borreliosis
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232541/
https://www.ncbi.nlm.nih.gov/pubmed/30429707
http://dx.doi.org/10.5114/ada.2018.77240
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