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Male and female genital lichen sclerosus. Clinical and functional classification criteria
INTRODUCTION: Lichen sclerosus (LS) is a chronic inflammatory disease affecting mainly the genital mucous membranes in both sexes. In the past, different terms were used to describe the disease, rendering a unique and specific clinical classification impossible. AIM: New therapeutic approaches are b...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232547/ https://www.ncbi.nlm.nih.gov/pubmed/30429700 http://dx.doi.org/10.5114/ada.2018.77236 |
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author | Latini, Alessandra Cota, Carlo Orsini, Diego Cristaudo, Antonio Tedesco, Marinella |
author_facet | Latini, Alessandra Cota, Carlo Orsini, Diego Cristaudo, Antonio Tedesco, Marinella |
author_sort | Latini, Alessandra |
collection | PubMed |
description | INTRODUCTION: Lichen sclerosus (LS) is a chronic inflammatory disease affecting mainly the genital mucous membranes in both sexes. In the past, different terms were used to describe the disease, rendering a unique and specific clinical classification impossible. AIM: New therapeutic approaches are being defined, which may contribute to a proper clinical management, however, a stage classification is essential to better define appropriate treatment for every stage of the disease. MATERIAL AND METHODS: One hundred and fifteen patients (50 women and 65 men) with a diagnosis of LS were enrolled between January 2014 and September 2016. All patients underwent cutaneous biopsy to confirm the clinical diagnosis of LS. Clinical and symptomatological parameters were used in order to put the patients into the correct stage of LS. The Dermatology Life Quality Index (DLQI) was used to classify patients based on subjective symptoms. Different cutaneous alterations and structural modifications of the genital mucosa were also taken into consideration in order to assign every patient to a specific stage. CONCLUSIONS: Lichen sclerosus is clinically described differently in females and in males and every form of LS is put into one of two stages according to the degree of severity: early and late stages. Within the clinical practice, it is useful to screen patients for groups of early or late forms of the disease in order to obtain a uniform subdivision of patients: those who may benefit from localized treatments, require a systemic drug and must undergo physical treatments (surgical, stem cells infiltrations). |
format | Online Article Text |
id | pubmed-6232547 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-62325472018-11-14 Male and female genital lichen sclerosus. Clinical and functional classification criteria Latini, Alessandra Cota, Carlo Orsini, Diego Cristaudo, Antonio Tedesco, Marinella Postepy Dermatol Alergol Original Paper INTRODUCTION: Lichen sclerosus (LS) is a chronic inflammatory disease affecting mainly the genital mucous membranes in both sexes. In the past, different terms were used to describe the disease, rendering a unique and specific clinical classification impossible. AIM: New therapeutic approaches are being defined, which may contribute to a proper clinical management, however, a stage classification is essential to better define appropriate treatment for every stage of the disease. MATERIAL AND METHODS: One hundred and fifteen patients (50 women and 65 men) with a diagnosis of LS were enrolled between January 2014 and September 2016. All patients underwent cutaneous biopsy to confirm the clinical diagnosis of LS. Clinical and symptomatological parameters were used in order to put the patients into the correct stage of LS. The Dermatology Life Quality Index (DLQI) was used to classify patients based on subjective symptoms. Different cutaneous alterations and structural modifications of the genital mucosa were also taken into consideration in order to assign every patient to a specific stage. CONCLUSIONS: Lichen sclerosus is clinically described differently in females and in males and every form of LS is put into one of two stages according to the degree of severity: early and late stages. Within the clinical practice, it is useful to screen patients for groups of early or late forms of the disease in order to obtain a uniform subdivision of patients: those who may benefit from localized treatments, require a systemic drug and must undergo physical treatments (surgical, stem cells infiltrations). Termedia Publishing House 2018-07-19 2018-10 /pmc/articles/PMC6232547/ /pubmed/30429700 http://dx.doi.org/10.5114/ada.2018.77236 Text en Copyright: © 2018 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Original Paper Latini, Alessandra Cota, Carlo Orsini, Diego Cristaudo, Antonio Tedesco, Marinella Male and female genital lichen sclerosus. Clinical and functional classification criteria |
title | Male and female genital lichen sclerosus. Clinical and functional classification criteria |
title_full | Male and female genital lichen sclerosus. Clinical and functional classification criteria |
title_fullStr | Male and female genital lichen sclerosus. Clinical and functional classification criteria |
title_full_unstemmed | Male and female genital lichen sclerosus. Clinical and functional classification criteria |
title_short | Male and female genital lichen sclerosus. Clinical and functional classification criteria |
title_sort | male and female genital lichen sclerosus. clinical and functional classification criteria |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232547/ https://www.ncbi.nlm.nih.gov/pubmed/30429700 http://dx.doi.org/10.5114/ada.2018.77236 |
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