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Item-Wise Interindividual Brain-Behavior Correlation in Task Neuroimaging Analysis
Brain-behavior correlations are commonly used to explore the associations between the brain and human behavior in cognitive neuroscience studies. There are many critics of the correlation approach, however. Most problems associated with correlation approaches originate in the weak statistical power...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232611/ https://www.ncbi.nlm.nih.gov/pubmed/30459550 http://dx.doi.org/10.3389/fnins.2018.00817 |
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author | Zhou, Xinlin Li, Mengyi Zhou, Hantao Li, Leinian Cui, Jiaxin |
author_facet | Zhou, Xinlin Li, Mengyi Zhou, Hantao Li, Leinian Cui, Jiaxin |
author_sort | Zhou, Xinlin |
collection | PubMed |
description | Brain-behavior correlations are commonly used to explore the associations between the brain and human behavior in cognitive neuroscience studies. There are many critics of the correlation approach, however. Most problems associated with correlation approaches originate in the weak statistical power of traditional correlation procedures (i.e., the mean-wise interindividual brain-behavior correlation). This paper proposes a new correlation procedure, the item-wise interindividual brain-behavior correlation, which enhances statistical power via testing the significance of small correlation coefficients from trials against zero rather than simply pursuing the highest correlation coefficient. The item-wise and mean-wise correlation were compared in simulations and an fMRI experiment on mathematical problem-solving. Simulations show that the item-wise correlation relative to the mean-wise correlation results in higher t-values when signal-to-noise ratio is equal to or larger than 6%. Item-wise correlation displayed more voxels with significant brain-behavior correlation than did mean-wise correlation. Analyses with item-wise (rather than mean-wise) correlation showed significant brain-behavior correlation at the threshold of p < 0.05 corrected. Cross validation showed that odd- and even-ordered trials have greater stability in terms of the item-wise correlation (r = 0.918) than the mean-wise correlation (r = 0.686). The simulations and example analyses altogether demonstrate the effectiveness of the proposed correlation procedure for task neuroimaging studies. |
format | Online Article Text |
id | pubmed-6232611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62326112018-11-20 Item-Wise Interindividual Brain-Behavior Correlation in Task Neuroimaging Analysis Zhou, Xinlin Li, Mengyi Zhou, Hantao Li, Leinian Cui, Jiaxin Front Neurosci Neuroscience Brain-behavior correlations are commonly used to explore the associations between the brain and human behavior in cognitive neuroscience studies. There are many critics of the correlation approach, however. Most problems associated with correlation approaches originate in the weak statistical power of traditional correlation procedures (i.e., the mean-wise interindividual brain-behavior correlation). This paper proposes a new correlation procedure, the item-wise interindividual brain-behavior correlation, which enhances statistical power via testing the significance of small correlation coefficients from trials against zero rather than simply pursuing the highest correlation coefficient. The item-wise and mean-wise correlation were compared in simulations and an fMRI experiment on mathematical problem-solving. Simulations show that the item-wise correlation relative to the mean-wise correlation results in higher t-values when signal-to-noise ratio is equal to or larger than 6%. Item-wise correlation displayed more voxels with significant brain-behavior correlation than did mean-wise correlation. Analyses with item-wise (rather than mean-wise) correlation showed significant brain-behavior correlation at the threshold of p < 0.05 corrected. Cross validation showed that odd- and even-ordered trials have greater stability in terms of the item-wise correlation (r = 0.918) than the mean-wise correlation (r = 0.686). The simulations and example analyses altogether demonstrate the effectiveness of the proposed correlation procedure for task neuroimaging studies. Frontiers Media S.A. 2018-11-06 /pmc/articles/PMC6232611/ /pubmed/30459550 http://dx.doi.org/10.3389/fnins.2018.00817 Text en Copyright © 2018 Zhou, Li, Zhou, Li and Cui. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zhou, Xinlin Li, Mengyi Zhou, Hantao Li, Leinian Cui, Jiaxin Item-Wise Interindividual Brain-Behavior Correlation in Task Neuroimaging Analysis |
title | Item-Wise Interindividual Brain-Behavior Correlation in Task Neuroimaging Analysis |
title_full | Item-Wise Interindividual Brain-Behavior Correlation in Task Neuroimaging Analysis |
title_fullStr | Item-Wise Interindividual Brain-Behavior Correlation in Task Neuroimaging Analysis |
title_full_unstemmed | Item-Wise Interindividual Brain-Behavior Correlation in Task Neuroimaging Analysis |
title_short | Item-Wise Interindividual Brain-Behavior Correlation in Task Neuroimaging Analysis |
title_sort | item-wise interindividual brain-behavior correlation in task neuroimaging analysis |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232611/ https://www.ncbi.nlm.nih.gov/pubmed/30459550 http://dx.doi.org/10.3389/fnins.2018.00817 |
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