Thymineless Death by the Fluoropyrimidine Polymer F10 Involves Replication Fork Collapse and Is Enhanced by Chk1 Inhibition

We are developing the fluoropyrimidine polymer F10 to overcome limitations of 5-fluorouracil (5-FU) that result from inefficient metabolism to 5-fluoro-2′-deoxyuridine-5′-mono- and tri-phosphate, the deoxyribonucleotide metabolites that are responsible for 5-FU's anticancer activity. F10 is muc...

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Detalles Bibliográficos
Autores principales: Mani, Chinnadurai, Pai, Sachin, Papke, Cinta Maria, Palle, Komaraiah, Gmeiner, William H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2018
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232621/
https://www.ncbi.nlm.nih.gov/pubmed/30439567
http://dx.doi.org/10.1016/j.neo.2018.10.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232621/
https://www.ncbi.nlm.nih.gov/pubmed/30439567
http://dx.doi.org/10.1016/j.neo.2018.10.006

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