Cargando…

LC-HRMS data as a result of untargeted metabolomic profiling of human cerebrospinal fluid

Cerebrospinal fluid (CSF) is a key body fluid that maintains the homeostasis in central nervous system (CNS). As a biofluid whose content reflects the brain metabolic activity, the CSF is analyzed in the context of neurological diseases and is rarely collected from healthy subjects. For this reason,...

Descripción completa

Detalles Bibliográficos
Autores principales: Mehl, Florence, Gallart-Ayala, Héctor, Konz, Ioana, Teav, Tony, Oikonomidi, Aikaterini, Peyratout, Gwendoline, van der Velpen, Vera, Popp, Julius, Ivanisevic, Julijana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232650/
https://www.ncbi.nlm.nih.gov/pubmed/30456258
http://dx.doi.org/10.1016/j.dib.2018.10.113
_version_ 1783370431902777344
author Mehl, Florence
Gallart-Ayala, Héctor
Konz, Ioana
Teav, Tony
Oikonomidi, Aikaterini
Peyratout, Gwendoline
van der Velpen, Vera
Popp, Julius
Ivanisevic, Julijana
author_facet Mehl, Florence
Gallart-Ayala, Héctor
Konz, Ioana
Teav, Tony
Oikonomidi, Aikaterini
Peyratout, Gwendoline
van der Velpen, Vera
Popp, Julius
Ivanisevic, Julijana
author_sort Mehl, Florence
collection PubMed
description Cerebrospinal fluid (CSF) is a key body fluid that maintains the homeostasis in central nervous system (CNS). As a biofluid whose content reflects the brain metabolic activity, the CSF is analyzed in the context of neurological diseases and is rarely collected from healthy subjects. For this reason, the metabolite variation associated with general phenotypic characteristics such as gender and age have hardly ever been studied. Here we present the hydrophilic interaction liquid chromatography-high resolution mass spectrometry (HILIC-HRMS) data as a result of untargeted metabolomics analysis of a cohort of elderly cognitively healthy volunteers (n = 32). 146 unambiguously identified water soluble metabolites (using accurate mass, retention time and MS/MS matching against spectral libraries) were measured and their abundances across all the subjects depending on their gender are provided in this article. Data tables are available at https://data.mendeley.com/datasets/c73xtsd4s5/1. it's published on mendeley, the DOI is DOI:10.17632/c73xtsd4s5.1. The data presented in this article are related to the research article entitled “A global HILIC-MS approach to measure polar human cerebrospinal fluid metabolome: Exploring gender-associated variation in a cohort of elderly cognitively healthy subjects” (Gallart-Ayala et al., 2018, In press).
format Online
Article
Text
id pubmed-6232650
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-62326502018-11-19 LC-HRMS data as a result of untargeted metabolomic profiling of human cerebrospinal fluid Mehl, Florence Gallart-Ayala, Héctor Konz, Ioana Teav, Tony Oikonomidi, Aikaterini Peyratout, Gwendoline van der Velpen, Vera Popp, Julius Ivanisevic, Julijana Data Brief Biochemistry, Genetics and Molecular Biology Cerebrospinal fluid (CSF) is a key body fluid that maintains the homeostasis in central nervous system (CNS). As a biofluid whose content reflects the brain metabolic activity, the CSF is analyzed in the context of neurological diseases and is rarely collected from healthy subjects. For this reason, the metabolite variation associated with general phenotypic characteristics such as gender and age have hardly ever been studied. Here we present the hydrophilic interaction liquid chromatography-high resolution mass spectrometry (HILIC-HRMS) data as a result of untargeted metabolomics analysis of a cohort of elderly cognitively healthy volunteers (n = 32). 146 unambiguously identified water soluble metabolites (using accurate mass, retention time and MS/MS matching against spectral libraries) were measured and their abundances across all the subjects depending on their gender are provided in this article. Data tables are available at https://data.mendeley.com/datasets/c73xtsd4s5/1. it's published on mendeley, the DOI is DOI:10.17632/c73xtsd4s5.1. The data presented in this article are related to the research article entitled “A global HILIC-MS approach to measure polar human cerebrospinal fluid metabolome: Exploring gender-associated variation in a cohort of elderly cognitively healthy subjects” (Gallart-Ayala et al., 2018, In press). Elsevier 2018-10-27 /pmc/articles/PMC6232650/ /pubmed/30456258 http://dx.doi.org/10.1016/j.dib.2018.10.113 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Biochemistry, Genetics and Molecular Biology
Mehl, Florence
Gallart-Ayala, Héctor
Konz, Ioana
Teav, Tony
Oikonomidi, Aikaterini
Peyratout, Gwendoline
van der Velpen, Vera
Popp, Julius
Ivanisevic, Julijana
LC-HRMS data as a result of untargeted metabolomic profiling of human cerebrospinal fluid
title LC-HRMS data as a result of untargeted metabolomic profiling of human cerebrospinal fluid
title_full LC-HRMS data as a result of untargeted metabolomic profiling of human cerebrospinal fluid
title_fullStr LC-HRMS data as a result of untargeted metabolomic profiling of human cerebrospinal fluid
title_full_unstemmed LC-HRMS data as a result of untargeted metabolomic profiling of human cerebrospinal fluid
title_short LC-HRMS data as a result of untargeted metabolomic profiling of human cerebrospinal fluid
title_sort lc-hrms data as a result of untargeted metabolomic profiling of human cerebrospinal fluid
topic Biochemistry, Genetics and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232650/
https://www.ncbi.nlm.nih.gov/pubmed/30456258
http://dx.doi.org/10.1016/j.dib.2018.10.113
work_keys_str_mv AT mehlflorence lchrmsdataasaresultofuntargetedmetabolomicprofilingofhumancerebrospinalfluid
AT gallartayalahector lchrmsdataasaresultofuntargetedmetabolomicprofilingofhumancerebrospinalfluid
AT konzioana lchrmsdataasaresultofuntargetedmetabolomicprofilingofhumancerebrospinalfluid
AT teavtony lchrmsdataasaresultofuntargetedmetabolomicprofilingofhumancerebrospinalfluid
AT oikonomidiaikaterini lchrmsdataasaresultofuntargetedmetabolomicprofilingofhumancerebrospinalfluid
AT peyratoutgwendoline lchrmsdataasaresultofuntargetedmetabolomicprofilingofhumancerebrospinalfluid
AT vandervelpenvera lchrmsdataasaresultofuntargetedmetabolomicprofilingofhumancerebrospinalfluid
AT poppjulius lchrmsdataasaresultofuntargetedmetabolomicprofilingofhumancerebrospinalfluid
AT ivanisevicjulijana lchrmsdataasaresultofuntargetedmetabolomicprofilingofhumancerebrospinalfluid