Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration

Hypoxia, which characterizes most tumor tissues, can alter the function of different immune cell types, favoring tumor escape mechanisms. In this study, we show that hypoxia profoundly acts on NK cells by influencing their transcriptome, affecting their immunoregulatory functions, and changing the c...

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Detalles Bibliográficos
Autores principales: Parodi, Monica, Raggi, Federica, Cangelosi, Davide, Manzini, Claudia, Balsamo, Mirna, Blengio, Fabiola, Eva, Alessandra, Varesio, Luigi, Pietra, Gabriella, Moretta, Lorenzo, Mingari, Maria Cristina, Vitale, Massimo, Bosco, Maria Carla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232835/
https://www.ncbi.nlm.nih.gov/pubmed/30459756
http://dx.doi.org/10.3389/fimmu.2018.02358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232835/
https://www.ncbi.nlm.nih.gov/pubmed/30459756
http://dx.doi.org/10.3389/fimmu.2018.02358

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