Cargando…

Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration

Hypoxia, which characterizes most tumor tissues, can alter the function of different immune cell types, favoring tumor escape mechanisms. In this study, we show that hypoxia profoundly acts on NK cells by influencing their transcriptome, affecting their immunoregulatory functions, and changing the c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Parodi, Monica, Raggi, Federica, Cangelosi, Davide, Manzini, Claudia, Balsamo, Mirna, Blengio, Fabiola, Eva, Alessandra, Varesio, Luigi, Pietra, Gabriella, Moretta, Lorenzo, Mingari, Maria Cristina, Vitale, Massimo, Bosco, Maria Carla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232835/ https://www.ncbi.nlm.nih.gov/pubmed/30459756 http://dx.doi.org/10.3389/fimmu.2018.02358

Ejemplares similares

Melanoma immunoediting by NK cells
por: Balsamo, Mirna, et al.
Publicado: (2012)

How melanoma cells inactivate NK cells
por: Pietra, Gabriella, et al.
Publicado: (2012)

Exploiting Human NK Cells in Tumor Therapy
por: Vacca, Paola, et al.
Publicado: (2020)

NK Cells, Tumor Cell Transition, and Tumor Progression in Solid Malignancies: New Hints for NK-Based Immunotherapy?
por: Cantoni, Claudia, et al.
Publicado: (2016)

IL-27 Imparts Immunoregulatory Function to Human NK Cell Subsets
por: Laroni, Alice, et al.
Publicado: (2011)

Cytokines can counteract the inhibitory effect of MEK-i on NK-cell function
por: Manzini, Claudia, et al.
Publicado: (2016)

Effect of Tyrosin Kinase Inhibitors on NK Cell and ILC3 Development and Function
por: Damele, Laura, et al.
Publicado: (2018)

NK Cells and Other Innate Lymphoid Cells in Hematopoietic Stem Cell Transplantation
por: Vacca, Paola, et al.
Publicado: (2016)

Unique Eomes(+) NK Cell Subsets Are Present in Uterus and Decidua During Early Pregnancy
por: Montaldo, Elisa, et al.
Publicado: (2016)

Heterogeneity of NK Cells and Other Innate Lymphoid Cells in Human and Murine Decidua
por: Vacca, Paola, et al.
Publicado: (2019)

Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation
por: Pende, Daniela, et al.
Publicado: (2019)

Human NK Cells: From Surface Receptors to the Therapy of Leukemias and Solid Tumors
por: Moretta, Lorenzo, et al.
Publicado: (2014)

Targeted Therapies: Friends or Foes for Patient’s NK Cell-Mediated Tumor Immune-Surveillance?
por: Damele, Laura, et al.
Publicado: (2020)

Wilms’ Tumor Primary Cells Display Potent Immunoregulatory Properties on NK Cells and Macrophages
por: Fiore, Piera Filomena, et al.
Publicado: (2021)

Human NK cells, their receptors and function [Image: see text]
por: Quatrini, Linda, et al.
Publicado: (2021)

Susceptibility of Human Melanoma Cells to Autologous Natural Killer (NK) Cell Killing: HLA-Related Effector Mechanisms and Role of Unlicensed NK Cells
por: Carrega, Paolo, et al.
Publicado: (2009)

Immunoregulatory Role of NK Cells in Tissue Inflammation and Regeneration
por: Tosello-Trampont, Annie, et al.
Publicado: (2017)

NK cells from malignant pleural effusions are potent antitumor effectors: A clue for adoptive immunotherapy?
por: Vacca, Paola, et al.
Publicado: (2013)

Human NK Cell Subsets Redistribution in Pathological Conditions: A Role for CCR7 Receptor
por: Pesce, Silvia, et al.
Publicado: (2016)

Features of Memory-Like and PD-1(+) Human NK Cell Subsets
por: Della Chiesa, Mariella, et al.
Publicado: (2016)

Cellular and molecular basis of haploidentical hematopoietic stem cell transplantation in the successful treatment of high-risk leukemias: role of alloreactive NK cells
por: Locatelli, Franco, et al.
Publicado: (2013)

Genetic Causes of Human NK Cell Deficiency and Their Effect on NK Cell Subsets
por: Mace, Emily M., et al.
Publicado: (2016)

Aspergillus fumigatus responds to natural killer (NK) cells with upregulation of stress related genes and inhibits the immunoregulatory function of NK cells
por: Schneider, Andreas, et al.
Publicado: (2016)

Stromal Cells from Human Decidua Exert a Strong Inhibitory Effect on NK Cell Function and Dendritic Cell Differentiation
por: Croxatto, Daniele, et al.
Publicado: (2014)

Inhibitory Receptors and Checkpoints in Human NK Cells, Implications for the Immunotherapy of Cancer
por: Sivori, Simona, et al.
Publicado: (2020)

Characterization of KIR (+) NK cell subsets with a monoclonal antibody selectively recognizing KIR2DL1 and blocking the specific interaction with HLA‐C
por: Meazza, Raffaella, et al.
Publicado: (2022)

Transcriptome analysis defines myocardium gene signatures in children with ToF and ASD and reveals disease-specific molecular reprogramming in response to surgery with cardiopulmonary bypass
por: Raggi, Federica, et al.
Publicado: (2020)

Dominant cytotoxic NK cell subset within CLPD-NK patients identifies a more aggressive NK cell proliferation
por: Barilà, Gregorio, et al.
Publicado: (2018)

Circulating NK cells and their subsets in Behçet's disease
por: Hasan, M. S., et al.
Publicado: (2017)

Use of Attribute Driven Incremental Discretization and Logic Learning Machine to build a prognostic classifier for neuroblastoma patients
por: Cangelosi, Davide, et al.
Publicado: (2014)

Overcoming hypoxia-induced functional suppression of NK cells
por: Solocinski, Kristen, et al.
Publicado: (2020)

The tumor microenvironment drives NK cell metabolic dysfunction leading to impaired antitumor activity
por: Tumino, Nicola, et al.
Publicado: (2022)

Generation of a Novel Regulatory NK Cell Subset from Peripheral Blood CD34(+) Progenitors Promoted by Membrane-Bound IL-15
por: Giuliani, Massimo, et al.
Publicado: (2008)

Murine models to study human NK cells in human solid tumors
por: Parodi, Monica, et al.
Publicado: (2023)

Identification of Novel Human NK Cell Progenitor Subsets
por: Sathe, Priyanka, et al.
Publicado: (2017)

Characterization of Surface Receptor Expression and Cytotoxicity of Human NK Cells and NK Cell Subsets in Overweight and Obese Humans
por: Naujoks, Wiebke, et al.
Publicado: (2020)

NK Cell Precursors in Human Bone Marrow in Health and Inflammation
por: Bozzano, Federica, et al.
Publicado: (2019)

The Emerging Role of HLA-E-Restricted CD8(+) T Lymphocytes in the Adaptive Immune Response to Pathogens and Tumors
por: Pietra, Gabriella, et al.
Publicado: (2010)

Reduction of the CD16(−)CD56(bright) NK Cell Subset Precedes NK Cell Dysfunction in Prostate Cancer
por: Koo, Kyo Chul, et al.
Publicado: (2013)

Phenotypic and Functional Characterization of NK Cells in αβT-Cell and B-Cell Depleted Haplo-HSCT to Cure Pediatric Patients with Acute Leukemia
por: Meazza, Raffaella, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9d6gn82nea1gfrmvol5r0e035v