Cargando…

Pravastatin Attenuates Acute Radiation-Induced Enteropathy and Improves Epithelial Cell Function

Background and Aim: Radiation-induced enteropathy is frequently observed after radiation therapy for abdominal and pelvic cancer or occurs secondary to accidental radiation exposure. The acute effects of irradiation on the intestine might be attributed to inhibition of mitosis in the crypts, as the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jang, Hyosun, Lee, Janet, Park, Sunhoo, Myung, Hyunwook, Kang, Jihoon, Kim, Kyuchang, Kim, Hyewon, Jang, Won-Suk, Lee, Sun-Joo, Shim, Sehwan, Myung, Jae K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232864/ https://www.ncbi.nlm.nih.gov/pubmed/30459609 http://dx.doi.org/10.3389/fphar.2018.01215

Ejemplares similares

Photobiomodulation Enhances the Angiogenic Effect of Mesenchymal Stem Cells to Mitigate Radiation-Induced Enteropathy
por: Kim, Kyuchang, et al.
Publicado: (2019)

Pravastatin Alleviates Radiation Proctitis by Regulating Thrombomodulin in Irradiated Endothelial Cells
por: Jang, Hyosun, et al.
Publicado: (2020)

Platelet-rich plasma activates AKT signaling to promote wound healing in a mouse model of radiation-induced skin injury
por: Lee, Janet, et al.
Publicado: (2019)

Metallothionein 2 activation by pravastatin reinforces epithelial integrity and ameliorates radiation-induced enteropathy
por: Kwak, Seo Young, et al.
Publicado: (2021)

Baicalein Mitigates Radiation-Induced Enteritis by Improving Endothelial Dysfunction
por: Jang, Hyosun, et al.
Publicado: (2019)

Combined Administration of Pravastatin and Metformin Attenuates Acute Radiation-Induced Intestinal Injury in Mouse and Minipig Models
por: Kim, Jung Moon, et al.
Publicado: (2022)

Impaired Skin Barrier Due to Sebaceous Gland Atrophy in the Latent Stage of Radiation-Induced Skin Injury: Application of Non-Invasive Diagnostic Methods
por: Jang, Hyosun, et al.
Publicado: (2018)

Metformin Protects the Intestinal Barrier by Activating Goblet Cell Maturation and Epithelial Proliferation in Radiation-Induced Enteropathy
por: Jang, Hyosun, et al.
Publicado: (2022)

Atorvastatin Inhibits Endothelial PAI-1-Mediated Monocyte Migration and Alleviates Radiation-Induced Enteropathy
por: Kwak, Seo Young, et al.
Publicado: (2021)

Centella asiatica-Derived Endothelial Paracrine Restores Epithelial Barrier Dysfunction in Radiation-Induced Enteritis
por: Kwak, Seo Young, et al.
Publicado: (2022)

Zileuton Alleviates Radiation-Induced Cutaneous Ulcers via Inhibition of Senescence-Associated Secretory Phenotype in Rodents
por: Park, Mineon, et al.
Publicado: (2022)

Effects of metformin and phenformin on apoptosis and epithelial‐mesenchymal transition in chemoresistant rectal cancer
por: Park, Ji‐Hye, et al.
Publicado: (2019)

ABCA1-Mediated EMT Promotes Papillary Thyroid Cancer Malignancy through the ERK/Fra-1/ZEB1 Pathway
por: Park, Ji-Hye, et al.
Publicado: (2023)

In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy
por: Jang, Won Hyuk, et al.
Publicado: (2016)

StemRegenin 1 Mitigates Radiation-Mediated Hematopoietic Injury by Modulating Radioresponse of Hematopoietic Stem/Progenitor Cells
por: Hwang, You Jung, et al.
Publicado: (2023)

Mesenchymal stem cell-mediated Notch2 activation overcomes radiation-induced injury of the hematopoietic system
por: Kim, Areumnuri, et al.
Publicado: (2018)

Radiation-Activated PI3K/AKT Pathway Promotes the Induction of Cancer Stem-Like Cells via the Upregulation of SOX2 in Colorectal Cancer
por: Park, Ji-Hye, et al.
Publicado: (2021)

Coniferyl Aldehyde Attenuates Radiation Enteropathy by Inhibiting Cell Death and Promoting Endothelial Cell Function
por: Jeong, Ye-Ji, et al.
Publicado: (2015)

Pentoxifylline Regulates Plasminogen Activator Inhibitor-1 Expression and Protein Kinase A Phosphorylation in Radiation-Induced Lung Fibrosis
por: Lee, Jong-Geol, et al.
Publicado: (2017)

Development of a minipig model for lung injury induced by a single high-dose radiation exposure and evaluation with thoracic computed tomography
por: Lee, Jong-Geol, et al.
Publicado: (2016)

Hyaluronic acid synthase 2 promotes malignant phenotypes of colorectal cancer cells through transforming growth factor beta signaling
por: Kim, Young‐Heon, et al.
Publicado: (2019)

Drug–drug Interaction between Pravastatin and Gemfibrozil (Antihyperlipidemic) with Gliclazide (Antidiabetic) in Rats
por: Sultanpur, CM, et al.
Publicado: (2010)

Pravastatin and placental insufficiency associated disorders: A systematic review and meta-analysis
por: Hirsch, Ayala, et al.
Publicado: (2022)

Pravastatin reduces plasma levels of extracellular vesicles in pregnancies at high risk of term preeclampsia
por: Santoyo, Jean Michell, et al.
Publicado: (2023)

Coenzyme Q10 or Creatine Counteract Pravastatin-Induced Liver Redox Changes in Hypercholesterolemic Mice
por: Marques, Ana C., et al.
Publicado: (2018)

Vitamin D Deficiency Impacts Exposure and Response of Pravastatin in Male Rats by Altering Hepatic OATPs
por: Peng, Jinfu, et al.
Publicado: (2022)

Inhibition of EphA2 by Dasatinib Suppresses Radiation-Induced Intestinal Injury
por: Kim, Areumnuri, et al.
Publicado: (2020)

Long-term culture-induced phenotypic difference and efficient cryopreservation of small intestinal organoids by treatment timing of Rho kinase inhibitor
por: Han, Sung-Hoon, et al.
Publicado: (2017)

Pravastatin Chronic Treatment Sensitizes Hypercholesterolemic Mice Muscle to Mitochondrial Permeability Transition: Protection by Creatine or Coenzyme Q(10)
por: Busanello, Estela N. B., et al.
Publicado: (2017)

Attenuation of Acetylcholine Activated Potassium Current (I(KACh)) by Simvastatin, Not Pravastatin in Mouse Atrial Cardiomyocyte: Possible Atrial Fibrillation Preventing Effects of Statin
por: Cho, Kyoung-Im, et al.
Publicado: (2014)

Elimination of Reprogramming Transgenes Facilitates the Differentiation of Induced Pluripotent Stem Cells into Hepatocyte-like Cells and Hepatic Organoids
por: Jeong, Jaemin, et al.
Publicado: (2022)

Effect of pravastatin on erythrocyte membrane fatty acid contents in patients with chronic kidney disease
por: Lee, Su Mi, et al.
Publicado: (2021)

Overexpression of dopamine receptor D2 promotes colorectal cancer progression by activating the β‐catenin/ZEB1 axis
por: Lee, Hyunjung, et al.
Publicado: (2021)

CD82 attenuates TGF-β1-mediated epithelial-mesenchymal transition by blocking smad-dependent signaling in ARPE-19 cells
por: Lee, Hyesook, et al.
Publicado: (2022)

Non-steroidal anti-inflammatory drug-induced enteropathy
por: Shin, Sung Jae, et al.
Publicado: (2017)

In Vitro Use of Cellular Synthetic Machinery for Biosensing Applications
por: Lee, Kyung-Ho, et al.
Publicado: (2019)

High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities
por: Parodi-Rullán, Rebecca M., et al.
Publicado: (2017)

Corrigendum: High Sensitivity of SIRT3 Deficient Hearts to Ischemia-Reperfusion Is Associated with Mitochondrial Abnormalities
por: Parodi-Rullán, Rebecca M., et al.
Publicado: (2017)

Comprehensive in vitro and in silico assessments of metabolic capabilities of 24 genomic variants of CYP2C19 using two different substrates
por: Seo, Myung-Eui, et al.
Publicado: (2023)

Pravastatin reduces radiation-induced damage in normal tissues
por: Doi, Hiroshi, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_0dua3oftt6r81abi1rdjjlqogv