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Compositional Dynamics of the Milk Fat Globule and Its Role in Infant Development
Human milk is uniquely optimized for the needs of the developing infant. Its composition is complex and dynamic, driven primarily by maternal genetics, and to a lesser extent by diet and environment. One important component that is gaining attention is the milk fat globule (MFG). The MFG is composed...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232911/ https://www.ncbi.nlm.nih.gov/pubmed/30460213 http://dx.doi.org/10.3389/fped.2018.00313 |
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author | Lee, Hanna Padhi, Emily Hasegawa, Yu Larke, Jules Parenti, Mariana Wang, Aidong Hernell, Olle Lönnerdal, Bo Slupsky, Carolyn |
author_facet | Lee, Hanna Padhi, Emily Hasegawa, Yu Larke, Jules Parenti, Mariana Wang, Aidong Hernell, Olle Lönnerdal, Bo Slupsky, Carolyn |
author_sort | Lee, Hanna |
collection | PubMed |
description | Human milk is uniquely optimized for the needs of the developing infant. Its composition is complex and dynamic, driven primarily by maternal genetics, and to a lesser extent by diet and environment. One important component that is gaining attention is the milk fat globule (MFG). The MFG is composed of a triglyceride-rich core surrounded by a tri-layer membrane, also known as the milk fat globule membrane (MFGM) that originates from mammary gland epithelia. The MFGM is enriched with glycerophospholipids, sphingolipids, cholesterol, and proteins, some of which are glycosylated, and are known to exert numerous biological roles. Mounting evidence suggests that the structure of the MFG and bioactive components of the MFGM may benefit the infant by aiding in the structural and functional maturation of the gut through the provision of essential nutrients and/or regulating various cellular events during infant growth and immune education. Further, antimicrobial peptides and surface carbohydrate moieties surrounding the MFG might have a pivotal role in shaping gut microbial populations, which in turn may promote protection against immune and inflammatory diseases early in life. This review seeks to: (1) understand the components of the MFG, as well as maternal factors including genetic and lifestyle factors that influence its characteristics; (2) examine the potential role of this milk component on the intestinal immune system; and (3) delineate the mechanistic roles of the MFG in infant intestinal maturation and establishment of the microbiota in the alimentary canal. |
format | Online Article Text |
id | pubmed-6232911 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62329112018-11-20 Compositional Dynamics of the Milk Fat Globule and Its Role in Infant Development Lee, Hanna Padhi, Emily Hasegawa, Yu Larke, Jules Parenti, Mariana Wang, Aidong Hernell, Olle Lönnerdal, Bo Slupsky, Carolyn Front Pediatr Pediatrics Human milk is uniquely optimized for the needs of the developing infant. Its composition is complex and dynamic, driven primarily by maternal genetics, and to a lesser extent by diet and environment. One important component that is gaining attention is the milk fat globule (MFG). The MFG is composed of a triglyceride-rich core surrounded by a tri-layer membrane, also known as the milk fat globule membrane (MFGM) that originates from mammary gland epithelia. The MFGM is enriched with glycerophospholipids, sphingolipids, cholesterol, and proteins, some of which are glycosylated, and are known to exert numerous biological roles. Mounting evidence suggests that the structure of the MFG and bioactive components of the MFGM may benefit the infant by aiding in the structural and functional maturation of the gut through the provision of essential nutrients and/or regulating various cellular events during infant growth and immune education. Further, antimicrobial peptides and surface carbohydrate moieties surrounding the MFG might have a pivotal role in shaping gut microbial populations, which in turn may promote protection against immune and inflammatory diseases early in life. This review seeks to: (1) understand the components of the MFG, as well as maternal factors including genetic and lifestyle factors that influence its characteristics; (2) examine the potential role of this milk component on the intestinal immune system; and (3) delineate the mechanistic roles of the MFG in infant intestinal maturation and establishment of the microbiota in the alimentary canal. Frontiers Media S.A. 2018-10-24 /pmc/articles/PMC6232911/ /pubmed/30460213 http://dx.doi.org/10.3389/fped.2018.00313 Text en Copyright © 2018 Lee, Padhi, Hasegawa, Larke, Parenti, Wang, Hernell, Lönnerdal and Slupsky. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Lee, Hanna Padhi, Emily Hasegawa, Yu Larke, Jules Parenti, Mariana Wang, Aidong Hernell, Olle Lönnerdal, Bo Slupsky, Carolyn Compositional Dynamics of the Milk Fat Globule and Its Role in Infant Development |
title | Compositional Dynamics of the Milk Fat Globule and Its Role in Infant Development |
title_full | Compositional Dynamics of the Milk Fat Globule and Its Role in Infant Development |
title_fullStr | Compositional Dynamics of the Milk Fat Globule and Its Role in Infant Development |
title_full_unstemmed | Compositional Dynamics of the Milk Fat Globule and Its Role in Infant Development |
title_short | Compositional Dynamics of the Milk Fat Globule and Its Role in Infant Development |
title_sort | compositional dynamics of the milk fat globule and its role in infant development |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232911/ https://www.ncbi.nlm.nih.gov/pubmed/30460213 http://dx.doi.org/10.3389/fped.2018.00313 |
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