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Cholesterol depletion enhances TGF-β Smad signaling by increasing c-Jun expression through a PKR-dependent mechanism

Transforming growth factor-β (TGF-β) plays critical roles in numerous physiological and pathological responses. Cholesterol, a major plasma membrane component, can have pronounced effects on signaling responses. Cells continually monitor cholesterol content and activate multilayered transcriptional...

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Detalles Bibliográficos
Autores principales:	Shapira, Keren E., Ehrlich, Marcelo, Henis, Yoav I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233055/ https://www.ncbi.nlm.nih.gov/pubmed/30091670 http://dx.doi.org/10.1091/mbc.E18-03-0175

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