Cargando…

Mechanisms underlying contrast-dependent orientation selectivity in mouse V1

Recent experiments have shown that mouse primary visual cortex (V1) is very different from that of cat or monkey, including response properties—one of which is that contrast invariance in the orientation selectivity (OS) of the neurons’ firing rates is replaced in mouse with contrast-dependent sharp...

Descripción completa

Detalles Bibliográficos
Autores principales: Dai, Wei P., Zhou, Douglas, McLaughlin, David W., Cai, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233123/
https://www.ncbi.nlm.nih.gov/pubmed/30337480
http://dx.doi.org/10.1073/pnas.1719044115
_version_ 1783370522946437120
author Dai, Wei P.
Zhou, Douglas
McLaughlin, David W.
Cai, David
author_facet Dai, Wei P.
Zhou, Douglas
McLaughlin, David W.
Cai, David
author_sort Dai, Wei P.
collection PubMed
description Recent experiments have shown that mouse primary visual cortex (V1) is very different from that of cat or monkey, including response properties—one of which is that contrast invariance in the orientation selectivity (OS) of the neurons’ firing rates is replaced in mouse with contrast-dependent sharpening (broadening) of OS in excitatory (inhibitory) neurons. These differences indicate a different circuit design for mouse V1 than that of cat or monkey. Here we develop a large-scale computational model of an effective input layer of mouse V1. Constrained by experiment data, the model successfully reproduces experimentally observed response properties—for example, distributions of firing rates, orientation tuning widths, and response modulations of simple and complex neurons, including the contrast dependence of orientation tuning curves. Analysis of the model shows that strong feedback inhibition and strong orientation-preferential cortical excitation to the excitatory population are the predominant mechanisms underlying the contrast-sharpening of OS in excitatory neurons, while the contrast-broadening of OS in inhibitory neurons results from a strong but nonpreferential cortical excitation to these inhibitory neurons, with the resulting contrast-broadened inhibition producing a secondary enhancement on the contrast-sharpened OS of excitatory neurons. Finally, based on these mechanisms, we show that adjusting the detailed balances between the predominant mechanisms can lead to contrast invariance—providing insights for future studies on contrast dependence (invariance).
format Online
Article
Text
id pubmed-6233123
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher National Academy of Sciences
record_format MEDLINE/PubMed
spelling pubmed-62331232018-11-14 Mechanisms underlying contrast-dependent orientation selectivity in mouse V1 Dai, Wei P. Zhou, Douglas McLaughlin, David W. Cai, David Proc Natl Acad Sci U S A Biological Sciences Recent experiments have shown that mouse primary visual cortex (V1) is very different from that of cat or monkey, including response properties—one of which is that contrast invariance in the orientation selectivity (OS) of the neurons’ firing rates is replaced in mouse with contrast-dependent sharpening (broadening) of OS in excitatory (inhibitory) neurons. These differences indicate a different circuit design for mouse V1 than that of cat or monkey. Here we develop a large-scale computational model of an effective input layer of mouse V1. Constrained by experiment data, the model successfully reproduces experimentally observed response properties—for example, distributions of firing rates, orientation tuning widths, and response modulations of simple and complex neurons, including the contrast dependence of orientation tuning curves. Analysis of the model shows that strong feedback inhibition and strong orientation-preferential cortical excitation to the excitatory population are the predominant mechanisms underlying the contrast-sharpening of OS in excitatory neurons, while the contrast-broadening of OS in inhibitory neurons results from a strong but nonpreferential cortical excitation to these inhibitory neurons, with the resulting contrast-broadened inhibition producing a secondary enhancement on the contrast-sharpened OS of excitatory neurons. Finally, based on these mechanisms, we show that adjusting the detailed balances between the predominant mechanisms can lead to contrast invariance—providing insights for future studies on contrast dependence (invariance). National Academy of Sciences 2018-11-06 2018-10-18 /pmc/articles/PMC6233123/ /pubmed/30337480 http://dx.doi.org/10.1073/pnas.1719044115 Text en Copyright © 2018 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/ This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Dai, Wei P.
Zhou, Douglas
McLaughlin, David W.
Cai, David
Mechanisms underlying contrast-dependent orientation selectivity in mouse V1
title Mechanisms underlying contrast-dependent orientation selectivity in mouse V1
title_full Mechanisms underlying contrast-dependent orientation selectivity in mouse V1
title_fullStr Mechanisms underlying contrast-dependent orientation selectivity in mouse V1
title_full_unstemmed Mechanisms underlying contrast-dependent orientation selectivity in mouse V1
title_short Mechanisms underlying contrast-dependent orientation selectivity in mouse V1
title_sort mechanisms underlying contrast-dependent orientation selectivity in mouse v1
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233123/
https://www.ncbi.nlm.nih.gov/pubmed/30337480
http://dx.doi.org/10.1073/pnas.1719044115
work_keys_str_mv AT daiweip mechanismsunderlyingcontrastdependentorientationselectivityinmousev1
AT zhoudouglas mechanismsunderlyingcontrastdependentorientationselectivityinmousev1
AT mclaughlindavidw mechanismsunderlyingcontrastdependentorientationselectivityinmousev1
AT caidavid mechanismsunderlyingcontrastdependentorientationselectivityinmousev1