Small Molecule Antagonists of NAADP-Induced Ca(2+) Release in T-Lymphocytes Suggest Potential Therapeutic Agents for Autoimmune Disease

Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent Ca(2+)-releasing second messenger known to date, but the precise NAADP/Ca(2+) signalling mechanisms are still controversial. We report the synthesis of small-molecule inhibitors of NAADP-induced Ca(2+) release based upon the ni...

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Detalles Bibliográficos
Autores principales: Zhang, Bo, Watt, Joanna M, Cordiglieri, Chiara, Dammermann, Werner, Mahon, Mary F., Flügel, Alexander, Guse, Andreas H., Potter, Barry V. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233153/
https://www.ncbi.nlm.nih.gov/pubmed/30425261
http://dx.doi.org/10.1038/s41598-018-34917-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233153/
https://www.ncbi.nlm.nih.gov/pubmed/30425261
http://dx.doi.org/10.1038/s41598-018-34917-3

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