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Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury
Renal fibrosis, especially tubulointerstitial fibrosis, is the inevitable outcome of all progressive chronic kidney diseases (CKDs) and exerts a great health burden worldwide. For a long time, interests in renal fibrosis have been concentrated on fibroblasts and myofibroblasts. However, in recent ye...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233178/ https://www.ncbi.nlm.nih.gov/pubmed/30425237 http://dx.doi.org/10.1038/s41419-018-1157-x |
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author | Qi, Ruochen Yang, Cheng |
author_facet | Qi, Ruochen Yang, Cheng |
author_sort | Qi, Ruochen |
collection | PubMed |
description | Renal fibrosis, especially tubulointerstitial fibrosis, is the inevitable outcome of all progressive chronic kidney diseases (CKDs) and exerts a great health burden worldwide. For a long time, interests in renal fibrosis have been concentrated on fibroblasts and myofibroblasts. However, in recent years, growing numbers of studies have focused on the role of tubular epithelial cells (TECs). TECs, rather than a victim or bystander, are probably a neglected mediator in renal fibrosis, responding to a variety of injuries. The maladaptive repair mechanisms of TECs may be the key point in this process. In this review, we will focus on the role of TECs in tubulointerstitial fibrosis. We will follow the fate of a tubular cell and depict the intracellular changes after injury. We will then discuss how the repair mechanism of tubular cells becomes maladaptive, and we will finally discuss the intercellular crosstalk in the interstitium that ultimately proceeds tubulointerstitial fibrosis. |
format | Online Article Text |
id | pubmed-6233178 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-62331782018-11-14 Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury Qi, Ruochen Yang, Cheng Cell Death Dis Review Article Renal fibrosis, especially tubulointerstitial fibrosis, is the inevitable outcome of all progressive chronic kidney diseases (CKDs) and exerts a great health burden worldwide. For a long time, interests in renal fibrosis have been concentrated on fibroblasts and myofibroblasts. However, in recent years, growing numbers of studies have focused on the role of tubular epithelial cells (TECs). TECs, rather than a victim or bystander, are probably a neglected mediator in renal fibrosis, responding to a variety of injuries. The maladaptive repair mechanisms of TECs may be the key point in this process. In this review, we will focus on the role of TECs in tubulointerstitial fibrosis. We will follow the fate of a tubular cell and depict the intracellular changes after injury. We will then discuss how the repair mechanism of tubular cells becomes maladaptive, and we will finally discuss the intercellular crosstalk in the interstitium that ultimately proceeds tubulointerstitial fibrosis. Nature Publishing Group UK 2018-11-13 /pmc/articles/PMC6233178/ /pubmed/30425237 http://dx.doi.org/10.1038/s41419-018-1157-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article Qi, Ruochen Yang, Cheng Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury |
title | Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury |
title_full | Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury |
title_fullStr | Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury |
title_full_unstemmed | Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury |
title_short | Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury |
title_sort | renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233178/ https://www.ncbi.nlm.nih.gov/pubmed/30425237 http://dx.doi.org/10.1038/s41419-018-1157-x |
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