Cargando…

Unmasking GluN1/GluN3A excitatory glycine NMDA receptors

GluN3A and GluN3B are glycine-binding subunits belonging to the NMDA receptor (NMDAR) family that can assemble with the GluN1 subunit to form unconventional receptors activated by glycine alone. Functional characterization of GluN1/GluN3 NMDARs has been difficult. Here, we uncover two modalities tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grand, Teddy, Abi Gerges, Sarah, David, Mélissa, Diana, Marco A., Paoletti, Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233196/ https://www.ncbi.nlm.nih.gov/pubmed/30425244 http://dx.doi.org/10.1038/s41467-018-07236-4

Ejemplares similares

GluN2A and GluN2B NMDA receptors use distinct allosteric routes
por: Tian, Meilin, et al.
Publicado: (2021)

Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists
por: Rouzbeh, Nirvan, et al.
Publicado: (2023)

Activation of excitatory glycine NMDA receptors: At the mercy of a whimsical GluN1 subunit
por: He, Miaomiao, et al.
Publicado: (2023)

Subunit Arrangement and Phenylethanolamine Binding in GluN1/GluN2B NMDA Receptors
por: Karakas, Erkan, et al.
Publicado: (2011)

Structural features in the glycine-binding sites of the GluN1 and GluN3A subunits regulate the surface delivery of NMDA receptors
por: Skrenkova, Kristyna, et al.
Publicado: (2019)

GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity
por: Shipton, Olivia A., et al.
Publicado: (2014)

Identification of a Subtype-Selective Allosteric Inhibitor of GluN1/GluN3 NMDA Receptors
por: Zeng, Yue, et al.
Publicado: (2022)

A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors
por: Chopra, Divyan A., et al.
Publicado: (2017)

GluN1 and GluN2A NMDA Receptor Subunits Increase in the Hippocampus during Memory Consolidation in the Rat
por: Cercato, Magali C., et al.
Publicado: (2017)

GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits
por: Bossi, Simon, et al.
Publicado: (2022)

Local constraints in either the GluN1 or GluN2 subunit equally impair NMDA receptor pore opening
por: Talukder, Iehab, et al.
Publicado: (2011)

d-Serine agonism of GluN1-GluN3 NMDA receptors regulates the activity of enteric neurons and coordinates gut motility
por: Osorio, Nancy, et al.
Publicado: (2023)

Mg(2+) block properties of triheteromeric GluN1–GluN2B–GluN2D NMDA receptors on neonatal rat substantia nigra pars compacta dopaminergic neurones
por: Huang, Zhuo, et al.
Publicado: (2014)

Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors
por: McClymont, David W., et al.
Publicado: (2012)

The Nucleosome Assembly Protein TSPYL2 Regulates the Expression of NMDA Receptor Subunits GluN2A and GluN2B
por: Tsang, Ka Hing, et al.
Publicado: (2014)

The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences
por: McKay, Sean, et al.
Publicado: (2018)

Protons Potentiate GluN1/GluN3A Currents by Attenuating Their Desensitisation
por: Cummings, Kirstie A., et al.
Publicado: (2016)

Influence of GluN2 subunit identity on NMDA receptor function
por: Wyllie, D.J.A., et al.
Publicado: (2013)

Age-Dependent, Subunit Specific Action of Hydrogen Sulfide on GluN1/2A and GluN1/2B NMDA Receptors
por: Yakovlev, Aleksey V., et al.
Publicado: (2017)

The NMDA Receptor Subunit (GluN1 and GluN2A) Modulation Following Different Conditions of Cocaine Abstinence in Rat Brain Structures
por: Smaga, Irena, et al.
Publicado: (2021)

An Alternating GluN1-2-1-2 Subunit Arrangement in Mature NMDA Receptors
por: Riou, Morgane, et al.
Publicado: (2012)

Palmitoylation at Two Cysteine Clusters on the C-Terminus of GluN2A and GluN2B Differentially Control Synaptic Targeting of NMDA Receptors
por: Mattison, Hayley A., et al.
Publicado: (2012)

The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis
por: Üner, Aykut, et al.
Publicado: (2015)

Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes
por: Shelkar, Gajanan P., et al.
Publicado: (2019)

DYRK1A-mediated phosphorylation of GluN2A at Ser(1048) regulates the surface expression and channel activity of GluN1/GluN2A receptors
por: Grau, Cristina, et al.
Publicado: (2014)

GluN3A: An NMDA Receptor Subunit with Exquisite Properties and Functions
por: Kehoe, Laura A., et al.
Publicado: (2013)

Astrocytes increase the activity of synaptic GluN2B NMDA receptors
por: Hahn, Junghyun, et al.
Publicado: (2015)

Potential Roles for the GluN2D NMDA Receptor Subunit in Schizophrenia
por: Vinnakota, Chitra, et al.
Publicado: (2023)

GluN2B but Not GluN2A for Basal Dendritic Growth of Cortical Pyramidal Neurons
por: Gonda, Steffen, et al.
Publicado: (2020)

NMDA receptor GluN2A/GluN2B subunit ratio as synaptic trait of levodopa-induced dyskinesias: from experimental models to patients
por: Mellone, Manuela, et al.
Publicado: (2015)

Identification of a single amino acid in GluN1 that is critical for glycine-primed internalization of NMDA receptors
por: Han, Lu, et al.
Publicado: (2013)

Targeted NMDA Receptor Interventions for Autism: Developmentally Determined Expression of GluN2B and GluN2A-Containing Receptors and Balanced Allosteric Modulatory Approaches
por: Deutsch, Stephen I., et al.
Publicado: (2022)

Endocytosis of GluN2B-containing NMDA receptor mediates NMDA-induced excitotoxicity
por: Wu, Yu, et al.
Publicado: (2017)

GluN2B and GluN2D NMDARs dominate synaptic responses in the adult spinal cord
por: Hildebrand, Michael E., et al.
Publicado: (2014)

Glycine Potentiates AMPA Receptor Function through Metabotropic Activation of GluN2A-Containing NMDA Receptors
por: Li, Li-Jun, et al.
Publicado: (2016)

Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses
por: Ferreira, Joana S, et al.
Publicado: (2017)

GluN2 Subunit-Dependent Redox Modulation of NMDA Receptor Activation by Homocysteine
por: Sibarov, Dmitry A., et al.
Publicado: (2020)

Glycine triggers a non-ionotropic activity of GluN2A-containing NMDA receptors to confer neuroprotection
por: Hu, Rong, et al.
Publicado: (2016)

The NMDA receptor GluN2C subunit controls cortical excitatory-inhibitory balance, neuronal oscillations and cognitive function
por: Gupta, Subhash C., et al.
Publicado: (2016)

GluN2B and GluN2A-containing NMDAR are differentially involved in extinction memory destabilization and restabilization during reconsolidation
por: Radiske, Andressa, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dfj4597dsnfkh7olhei5dsuokt