Autoinhibition in Ras effectors Raf, PI3Kα, and RASSF5: a comprehensive review underscoring the challenges in pharmacological intervention

Autoinhibition is an effective mechanism that guards proteins against spurious activation. Despite its ubiquity, the distinct organizations of the autoinhibited states and their release mechanisms differ. Signaling is most responsive to the cell environment only if a small shift in the equilibrium i...

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Detalles Bibliográficos
Autores principales: Nussinov, Ruth, Zhang, Mingzhen, Tsai, Chung-Jung, Liao, Tsung-Jen, Fushman, David, Jang, Hyunbum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233353/
https://www.ncbi.nlm.nih.gov/pubmed/30269291
http://dx.doi.org/10.1007/s12551-018-0461-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233353/
https://www.ncbi.nlm.nih.gov/pubmed/30269291
http://dx.doi.org/10.1007/s12551-018-0461-0

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