LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer

BACKGROUND: Reprogrammed energy metabolism has become an emerging hallmark of cancer in recent years. Transporters have been reported to be amino acid sensors involved in controlling mTOR recruitment and activation, which is crucial for the growth of both normal and tumor cells. L-type amino acid tr...

Descripción completa

Detalles Bibliográficos
Autores principales: Feng, Mengyu, Xiong, Guangbing, Cao, Zhe, Yang, Gang, Zheng, Suli, Qiu, Jiangdong, You, Lei, Zheng, Lianfang, Zhang, Taiping, Zhao, Yupei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233565/
https://www.ncbi.nlm.nih.gov/pubmed/30419950
http://dx.doi.org/10.1186/s13046-018-0947-4

Ejemplares similares

Ejemplares similares