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Metabolic modeling and response surface analysis of an Escherichia coli strain engineered for shikimic acid production

BACKGROUND: Classic metabolic engineering strategies often induce significant flux imbalances to microbial metabolism, causing undesirable outcomes such as suboptimal conversion of substrates to products. Several mathematical frameworks have been developed to understand the physiological and metabol...

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Detalles Bibliográficos
Autores principales:	Martínez, Juan A., Rodriguez, Alberto, Moreno, Fabian, Flores, Noemí, Lara, Alvaro R., Ramírez, Octavio T., Gosset, Guillermo, Bolivar, Francisco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233605/ https://www.ncbi.nlm.nih.gov/pubmed/30419897 http://dx.doi.org/10.1186/s12918-018-0632-4

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