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Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster

Loss of gut integrity is linked to various human diseases including inflammatory bowel disease. However, the mechanisms that lead to loss of barrier function remain poorly understood. Using D. melanogaster, we demonstrate that dietary restriction (DR) slows the age-related decline in intestinal inte...

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Detalles Bibliográficos
Autores principales:	Akagi, Kazutaka, Wilson, Kenneth A., Katewa, Subhash D., Ortega, Mauricio, Simons, Jesse, Hilsabeck, Tyler A., Kapuria, Subir, Sharma, Amit, Jasper, Heinrich, Kapahi, Pankaj
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233930/ https://www.ncbi.nlm.nih.gov/pubmed/30383748 http://dx.doi.org/10.1371/journal.pgen.1007777

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