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Dynamic neuromuscular remodeling precedes motor-unit loss in a mouse model of ALS

Despite being an early event in ALS, it remains unclear whether the denervation of neuromuscular junctions (NMJ) is simply the first manifestation of a globally degenerating motor neuron. Using in vivo imaging of single axons and their NMJs over a three-month period, we identify that single motor-un...

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Detalles Bibliográficos
Autores principales:	Martineau, Éric, Di Polo, Adriana, Vande Velde, Christine, Robitaille, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234026/ https://www.ncbi.nlm.nih.gov/pubmed/30320556 http://dx.doi.org/10.7554/eLife.41973

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