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TGFβ1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of T(H)17 cells by an AHR-independent mechanism

The aryl hydrocarbon receptor (AHR) is a transcription factor activated by ligand highly expressed on T(H)17 cells, and AHR-deficient CD4(+) T cells have impaired production of IL-17A and IL-22. Although AHR activation can exacerbate in vivo T(H)17 cell-mediated autoimmunity, accumulating data indic...

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Detalles Bibliográficos
Autores principales:	de Lima, Kalil Alves, Donate, Paula Barbim, Talbot, Jhimmy, Davoli-Ferreira, Marcela, Peres, Raphael Sanches, Cunha, Thiago Mattar, Alves-Filho, José Carlos, Cunha, Fernando Queiroz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234206/ https://www.ncbi.nlm.nih.gov/pubmed/30425241 http://dx.doi.org/10.1038/s41419-018-1107-7

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