Broad neutralizing activity of a human monoclonal antibody against H7N9 strains from 2013 to 2017

H7N9 influenza virus has been circulating among humans for five epidemic waves since it was first isolated in 2013 in China. The recent increase in H7N9 infections during the fifth outbreak in China has caused concerns of a possible pandemic. In this study, we describe a previously characterized hum...

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Autores principales: Chen, Cong, Liu, Zuliang, Liu, Liguo, Xiao, Yan, Wang, Jianmin, Jin, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234208/
https://www.ncbi.nlm.nih.gov/pubmed/30425238
http://dx.doi.org/10.1038/s41426-018-0182-2
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author Chen, Cong
Liu, Zuliang
Liu, Liguo
Xiao, Yan
Wang, Jianmin
Jin, Qi
author_facet Chen, Cong
Liu, Zuliang
Liu, Liguo
Xiao, Yan
Wang, Jianmin
Jin, Qi
author_sort Chen, Cong
collection PubMed
description H7N9 influenza virus has been circulating among humans for five epidemic waves since it was first isolated in 2013 in China. The recent increase in H7N9 infections during the fifth outbreak in China has caused concerns of a possible pandemic. In this study, we describe a previously characterized human monoclonal antibody, HNIgGA6, obtained by isolating rearranged heavy-chain and light-chain genes from patients who had recovered from H7N9 infections. HNIgGA6 recognized multiple HAs and neutralized the infectivity of 11 out of the 12 H7N9 strains tested, as well as three emerging HPAI H7N9 isolates. The only resistant strain was A/Shanghai/1/2013 (H7N9-SH1), which carries the avian receptor alleles 186V and 226Q in the sialic acid-binding pocket. The mAb broadly neutralized divergent H7N9 strains from 2013 to 2017 and represents a potential alternative treatment for H7N9 interventions.
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spelling pubmed-62342082018-11-19 Broad neutralizing activity of a human monoclonal antibody against H7N9 strains from 2013 to 2017 Chen, Cong Liu, Zuliang Liu, Liguo Xiao, Yan Wang, Jianmin Jin, Qi Emerg Microbes Infect Article H7N9 influenza virus has been circulating among humans for five epidemic waves since it was first isolated in 2013 in China. The recent increase in H7N9 infections during the fifth outbreak in China has caused concerns of a possible pandemic. In this study, we describe a previously characterized human monoclonal antibody, HNIgGA6, obtained by isolating rearranged heavy-chain and light-chain genes from patients who had recovered from H7N9 infections. HNIgGA6 recognized multiple HAs and neutralized the infectivity of 11 out of the 12 H7N9 strains tested, as well as three emerging HPAI H7N9 isolates. The only resistant strain was A/Shanghai/1/2013 (H7N9-SH1), which carries the avian receptor alleles 186V and 226Q in the sialic acid-binding pocket. The mAb broadly neutralized divergent H7N9 strains from 2013 to 2017 and represents a potential alternative treatment for H7N9 interventions. Nature Publishing Group UK 2018-11-14 /pmc/articles/PMC6234208/ /pubmed/30425238 http://dx.doi.org/10.1038/s41426-018-0182-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chen, Cong
Liu, Zuliang
Liu, Liguo
Xiao, Yan
Wang, Jianmin
Jin, Qi
Broad neutralizing activity of a human monoclonal antibody against H7N9 strains from 2013 to 2017
title Broad neutralizing activity of a human monoclonal antibody against H7N9 strains from 2013 to 2017
title_full Broad neutralizing activity of a human monoclonal antibody against H7N9 strains from 2013 to 2017
title_fullStr Broad neutralizing activity of a human monoclonal antibody against H7N9 strains from 2013 to 2017
title_full_unstemmed Broad neutralizing activity of a human monoclonal antibody against H7N9 strains from 2013 to 2017
title_short Broad neutralizing activity of a human monoclonal antibody against H7N9 strains from 2013 to 2017
title_sort broad neutralizing activity of a human monoclonal antibody against h7n9 strains from 2013 to 2017
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234208/
https://www.ncbi.nlm.nih.gov/pubmed/30425238
http://dx.doi.org/10.1038/s41426-018-0182-2
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