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A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234216/ https://www.ncbi.nlm.nih.gov/pubmed/30425247 http://dx.doi.org/10.1038/s41467-018-07019-x |
| _version_ | 1783370659659776000 |
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| author | Hansen, Lea B. S. Roager, Henrik M. Søndertoft, Nadja B. Gøbel, Rikke J. Kristensen, Mette Vallès-Colomer, Mireia Vieira-Silva, Sara Ibrügger, Sabine Lind, Mads V. Mærkedahl, Rasmus B. Bahl, Martin I. Madsen, Mia L. Havelund, Jesper Falony, Gwen Tetens, Inge Nielsen, Trine Allin, Kristine H. Frandsen, Henrik L. Hartmann, Bolette Holst, Jens Juul Sparholt, Morten H. Holck, Jesper Blennow, Andreas Moll, Janne Marie Meyer, Anne S. Hoppe, Camilla Poulsen, Jørgen H. Carvalho, Vera Sagnelli, Domenico Dalgaard, Marlene D. Christensen, Anders F. Lydolph, Magnus Christian Ross, Alastair B. Villas-Bôas, Silas Brix, Susanne Sicheritz-Pontén, Thomas Buschard, Karsten Linneberg, Allan Rumessen, Jüri J. Ekstrøm, Claus T. Ritz, Christian Kristiansen, Karsten Nielsen, H. Bjørn Vestergaard, Henrik Færgeman, Nils J. Raes, Jeroen Frøkiær, Hanne Hansen, Torben Lauritzen, Lotte Gupta, Ramneek Licht, Tine Rask Pedersen, Oluf |
| author_facet | Hansen, Lea B. S. Roager, Henrik M. Søndertoft, Nadja B. Gøbel, Rikke J. Kristensen, Mette Vallès-Colomer, Mireia Vieira-Silva, Sara Ibrügger, Sabine Lind, Mads V. Mærkedahl, Rasmus B. Bahl, Martin I. Madsen, Mia L. Havelund, Jesper Falony, Gwen Tetens, Inge Nielsen, Trine Allin, Kristine H. Frandsen, Henrik L. Hartmann, Bolette Holst, Jens Juul Sparholt, Morten H. Holck, Jesper Blennow, Andreas Moll, Janne Marie Meyer, Anne S. Hoppe, Camilla Poulsen, Jørgen H. Carvalho, Vera Sagnelli, Domenico Dalgaard, Marlene D. Christensen, Anders F. Lydolph, Magnus Christian Ross, Alastair B. Villas-Bôas, Silas Brix, Susanne Sicheritz-Pontén, Thomas Buschard, Karsten Linneberg, Allan Rumessen, Jüri J. Ekstrøm, Claus T. Ritz, Christian Kristiansen, Karsten Nielsen, H. Bjørn Vestergaard, Henrik Færgeman, Nils J. Raes, Jeroen Frøkiær, Hanne Hansen, Torben Lauritzen, Lotte Gupta, Ramneek Licht, Tine Rask Pedersen, Oluf |
| author_sort | Hansen, Lea B. S. |
| collection | PubMed |
| description | Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres. |
| format | Online Article Text |
| id | pubmed-6234216 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-62342162018-11-15 A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults Hansen, Lea B. S. Roager, Henrik M. Søndertoft, Nadja B. Gøbel, Rikke J. Kristensen, Mette Vallès-Colomer, Mireia Vieira-Silva, Sara Ibrügger, Sabine Lind, Mads V. Mærkedahl, Rasmus B. Bahl, Martin I. Madsen, Mia L. Havelund, Jesper Falony, Gwen Tetens, Inge Nielsen, Trine Allin, Kristine H. Frandsen, Henrik L. Hartmann, Bolette Holst, Jens Juul Sparholt, Morten H. Holck, Jesper Blennow, Andreas Moll, Janne Marie Meyer, Anne S. Hoppe, Camilla Poulsen, Jørgen H. Carvalho, Vera Sagnelli, Domenico Dalgaard, Marlene D. Christensen, Anders F. Lydolph, Magnus Christian Ross, Alastair B. Villas-Bôas, Silas Brix, Susanne Sicheritz-Pontén, Thomas Buschard, Karsten Linneberg, Allan Rumessen, Jüri J. Ekstrøm, Claus T. Ritz, Christian Kristiansen, Karsten Nielsen, H. Bjørn Vestergaard, Henrik Færgeman, Nils J. Raes, Jeroen Frøkiær, Hanne Hansen, Torben Lauritzen, Lotte Gupta, Ramneek Licht, Tine Rask Pedersen, Oluf Nat Commun Article Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres. Nature Publishing Group UK 2018-11-13 /pmc/articles/PMC6234216/ /pubmed/30425247 http://dx.doi.org/10.1038/s41467-018-07019-x Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Hansen, Lea B. S. Roager, Henrik M. Søndertoft, Nadja B. Gøbel, Rikke J. Kristensen, Mette Vallès-Colomer, Mireia Vieira-Silva, Sara Ibrügger, Sabine Lind, Mads V. Mærkedahl, Rasmus B. Bahl, Martin I. Madsen, Mia L. Havelund, Jesper Falony, Gwen Tetens, Inge Nielsen, Trine Allin, Kristine H. Frandsen, Henrik L. Hartmann, Bolette Holst, Jens Juul Sparholt, Morten H. Holck, Jesper Blennow, Andreas Moll, Janne Marie Meyer, Anne S. Hoppe, Camilla Poulsen, Jørgen H. Carvalho, Vera Sagnelli, Domenico Dalgaard, Marlene D. Christensen, Anders F. Lydolph, Magnus Christian Ross, Alastair B. Villas-Bôas, Silas Brix, Susanne Sicheritz-Pontén, Thomas Buschard, Karsten Linneberg, Allan Rumessen, Jüri J. Ekstrøm, Claus T. Ritz, Christian Kristiansen, Karsten Nielsen, H. Bjørn Vestergaard, Henrik Færgeman, Nils J. Raes, Jeroen Frøkiær, Hanne Hansen, Torben Lauritzen, Lotte Gupta, Ramneek Licht, Tine Rask Pedersen, Oluf A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults |
| title | A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults |
| title_full | A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults |
| title_fullStr | A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults |
| title_full_unstemmed | A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults |
| title_short | A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults |
| title_sort | low-gluten diet induces changes in the intestinal microbiome of healthy danish adults |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234216/ https://www.ncbi.nlm.nih.gov/pubmed/30425247 http://dx.doi.org/10.1038/s41467-018-07019-x |
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