Immunogenomic Landscape Contributes to Hyperprogressive Disease after Anti-PD-1 Immunotherapy for Cancer

Although PD-1-blocking immunotherapies demonstrate significant therapeutic promise, a subset of the patients could develop hyperprogressive disease (HPD) with accelerated tumor growth after anti-PD1 immunotherapy. To elucidate the underlying mechanisms, we compared the mutational and transcriptional...

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Detalles Bibliográficos
Autores principales: Xiong, Donghai, Wang, Yian, Singavi, Arun K., Mackinnon, Alexander C., George, Ben, You, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234258/
https://www.ncbi.nlm.nih.gov/pubmed/30439581
http://dx.doi.org/10.1016/j.isci.2018.10.021

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