Composite Lymphoma Comprising Extranodal NK/T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma

We report a rare case of composite lymphoma comprising extranodal NK/T-cell lymphoma, nasal type, (ENKL) and diffuse large B-cell lymphoma (DLBCL) in a 70-year-old man complaining of fatigue. Computed tomography showed multiple consolidations in both lungs, and ENKL was diagnosed from transbronchial...

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Detalles Bibliográficos
Autores principales: Nagai, Shin, Hiraga, Junji, Suzuki, Noriyuki, Suzuki, Naruko, Takagi, Yusuke, Narita, Michihiko, Kagami, Yoshitoyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234446/
https://www.ncbi.nlm.nih.gov/pubmed/30515337
http://dx.doi.org/10.1155/2018/1583925
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author Nagai, Shin
Hiraga, Junji
Suzuki, Noriyuki
Suzuki, Naruko
Takagi, Yusuke
Narita, Michihiko
Kagami, Yoshitoyo
author_facet Nagai, Shin
Hiraga, Junji
Suzuki, Noriyuki
Suzuki, Naruko
Takagi, Yusuke
Narita, Michihiko
Kagami, Yoshitoyo
author_sort Nagai, Shin
collection PubMed
description We report a rare case of composite lymphoma comprising extranodal NK/T-cell lymphoma, nasal type, (ENKL) and diffuse large B-cell lymphoma (DLBCL) in a 70-year-old man complaining of fatigue. Computed tomography showed multiple consolidations in both lungs, and ENKL was diagnosed from transbronchial lung biopsy. Positron emission tomography also detected abnormal uptake in the stomach, and DLBCL was diagnosed from subsequent gastroscopy. Two courses of chemotherapy including rituximab achieved reduction in DLBCL, but ENKL proved resistant to this treatment and progressed. Concomitant ENKL and DLBCL have not been previously described among reports of composite lymphomas.
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spelling pubmed-62344462018-12-04 Composite Lymphoma Comprising Extranodal NK/T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma Nagai, Shin Hiraga, Junji Suzuki, Noriyuki Suzuki, Naruko Takagi, Yusuke Narita, Michihiko Kagami, Yoshitoyo Case Rep Hematol Case Report We report a rare case of composite lymphoma comprising extranodal NK/T-cell lymphoma, nasal type, (ENKL) and diffuse large B-cell lymphoma (DLBCL) in a 70-year-old man complaining of fatigue. Computed tomography showed multiple consolidations in both lungs, and ENKL was diagnosed from transbronchial lung biopsy. Positron emission tomography also detected abnormal uptake in the stomach, and DLBCL was diagnosed from subsequent gastroscopy. Two courses of chemotherapy including rituximab achieved reduction in DLBCL, but ENKL proved resistant to this treatment and progressed. Concomitant ENKL and DLBCL have not been previously described among reports of composite lymphomas. Hindawi 2018-10-31 /pmc/articles/PMC6234446/ /pubmed/30515337 http://dx.doi.org/10.1155/2018/1583925 Text en Copyright © 2018 Shin Nagai et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Nagai, Shin
Hiraga, Junji
Suzuki, Noriyuki
Suzuki, Naruko
Takagi, Yusuke
Narita, Michihiko
Kagami, Yoshitoyo
Composite Lymphoma Comprising Extranodal NK/T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma
title Composite Lymphoma Comprising Extranodal NK/T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma
title_full Composite Lymphoma Comprising Extranodal NK/T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma
title_fullStr Composite Lymphoma Comprising Extranodal NK/T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma
title_full_unstemmed Composite Lymphoma Comprising Extranodal NK/T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma
title_short Composite Lymphoma Comprising Extranodal NK/T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma
title_sort composite lymphoma comprising extranodal nk/t-cell lymphoma and diffuse large b-cell lymphoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234446/
https://www.ncbi.nlm.nih.gov/pubmed/30515337
http://dx.doi.org/10.1155/2018/1583925
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