Immunohistochemical characterization of stem cell and differentiation markers of the dental pulp of human natal teeth

AIM: Dental pulp stem cells, which are primarily derived from the pulp tissues of human teeth, have rarely been obtained from natal teeth. This study investigated the stem cell and differentiation markers of the dental pulp of natal teeth using immunohistochemistry. MATERIALS & METHODS: The pulp...

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Autores principales: Shetty, Heeresh, Kakade, Adesh, Shetty, Shishir, Neelakantan, Prasanna, Nagar, Saurabh, Desai, Rajiv S, Beri, Kavita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234461/
https://www.ncbi.nlm.nih.gov/pubmed/30450229
http://dx.doi.org/10.4155/fsoa-2018-0062
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author Shetty, Heeresh
Kakade, Adesh
Shetty, Shishir
Neelakantan, Prasanna
Nagar, Saurabh
Desai, Rajiv S
Beri, Kavita
author_facet Shetty, Heeresh
Kakade, Adesh
Shetty, Shishir
Neelakantan, Prasanna
Nagar, Saurabh
Desai, Rajiv S
Beri, Kavita
author_sort Shetty, Heeresh
collection PubMed
description AIM: Dental pulp stem cells, which are primarily derived from the pulp tissues of human teeth, have rarely been obtained from natal teeth. This study investigated the stem cell and differentiation markers of the dental pulp of natal teeth using immunohistochemistry. MATERIALS & METHODS: The pulp tissue from extracted natal teeth (n = 2) of a 20-day-old healthy male was examined for immunohistochemical expression of stem cell (Oct-4 and SOX 2) and differentiation markers (Nestin, CD 44, desmin, osteopontin and Ki- 67). RESULTS: The pulp tissue of the natal teeth expressed immunopositivity for nestin, CD 44 and SOX2. CONCLUSION: Natal teeth, if preserved properly, could serve as sources of dental pulp stem cells that are an improvement on deciduous teeth.
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spelling pubmed-62344612018-11-16 Immunohistochemical characterization of stem cell and differentiation markers of the dental pulp of human natal teeth Shetty, Heeresh Kakade, Adesh Shetty, Shishir Neelakantan, Prasanna Nagar, Saurabh Desai, Rajiv S Beri, Kavita Future Sci OA Research Article AIM: Dental pulp stem cells, which are primarily derived from the pulp tissues of human teeth, have rarely been obtained from natal teeth. This study investigated the stem cell and differentiation markers of the dental pulp of natal teeth using immunohistochemistry. MATERIALS & METHODS: The pulp tissue from extracted natal teeth (n = 2) of a 20-day-old healthy male was examined for immunohistochemical expression of stem cell (Oct-4 and SOX 2) and differentiation markers (Nestin, CD 44, desmin, osteopontin and Ki- 67). RESULTS: The pulp tissue of the natal teeth expressed immunopositivity for nestin, CD 44 and SOX2. CONCLUSION: Natal teeth, if preserved properly, could serve as sources of dental pulp stem cells that are an improvement on deciduous teeth. Future Science Ltd 2018-10-04 /pmc/articles/PMC6234461/ /pubmed/30450229 http://dx.doi.org/10.4155/fsoa-2018-0062 Text en © 2018 Kavita Beri This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Research Article
Shetty, Heeresh
Kakade, Adesh
Shetty, Shishir
Neelakantan, Prasanna
Nagar, Saurabh
Desai, Rajiv S
Beri, Kavita
Immunohistochemical characterization of stem cell and differentiation markers of the dental pulp of human natal teeth
title Immunohistochemical characterization of stem cell and differentiation markers of the dental pulp of human natal teeth
title_full Immunohistochemical characterization of stem cell and differentiation markers of the dental pulp of human natal teeth
title_fullStr Immunohistochemical characterization of stem cell and differentiation markers of the dental pulp of human natal teeth
title_full_unstemmed Immunohistochemical characterization of stem cell and differentiation markers of the dental pulp of human natal teeth
title_short Immunohistochemical characterization of stem cell and differentiation markers of the dental pulp of human natal teeth
title_sort immunohistochemical characterization of stem cell and differentiation markers of the dental pulp of human natal teeth
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234461/
https://www.ncbi.nlm.nih.gov/pubmed/30450229
http://dx.doi.org/10.4155/fsoa-2018-0062
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